Header

UZH-Logo

Maintenance Infos

Triethanolamine [MAK Value Documentation, 2018]


Hartwig, A; MAK Commission; Arand, Michael; et al (2019). Triethanolamine [MAK Value Documentation, 2018]. The MAK Collection for Occupational Health and Safety, 4(1):117-127.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of triethanolamine [102‐71‐6].
Critical effect is the inflammation of the larynx observed in a 28‐day study in rats with a BMDL05 of 14 mg/m3. An analysis of the studies with monoethanolamine, diethanolamine and 7 other studies with substances that cause inflammation of the larynx shows that the NOAEC in subchronic or chronic studies is lower than in subacute studies. Therefore, for a chronic exposure to triethanolamine at the workplace a decrease of the NOAEC cannot be excluded and the MAK value is lowered to 1 mg/m3 for the inhalable fraction.
Triethanolamine remains assigned to Peak Limitation Category I for locally acting substances. An excursion factor of 1 is set by analogy with the other ethanolamines.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of triethanolamine [102‐71‐6].
Critical effect is the inflammation of the larynx observed in a 28‐day study in rats with a BMDL05 of 14 mg/m3. An analysis of the studies with monoethanolamine, diethanolamine and 7 other studies with substances that cause inflammation of the larynx shows that the NOAEC in subchronic or chronic studies is lower than in subacute studies. Therefore, for a chronic exposure to triethanolamine at the workplace a decrease of the NOAEC cannot be excluded and the MAK value is lowered to 1 mg/m3 for the inhalable fraction.
Triethanolamine remains assigned to Peak Limitation Category I for locally acting substances. An excursion factor of 1 is set by analogy with the other ethanolamines.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

0 downloads since deposited on 21 Nov 2019
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:30 January 2019
Deposited On:21 Nov 2019 15:18
Last Modified:29 Jul 2020 11:44
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb10271kske6519

Download

Closed Access: Download allowed only for UZH members