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Wasserstoffperoxid [MAK Value Documentation in German language, 2019]


Hartwig, A; MAK Commission; Arand, Michael; et al (2019). Wasserstoffperoxid [MAK Value Documentation in German language, 2019]. The MAK Collection for Occupational Health and Safety, 4(1):194-199.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of hydrogen peroxide [7722‐84‐1] as new inhalation studies are available.
Hydrogen peroxide is an irritant to the respiratory tract and the eyes.
In a 90‐day inhalation study in the rat a NOAEC of 7 ml/m3 was determined, which confirms the previous 28‐day inhalation study and proves that the effects at the respiratory tract do not increase with exposure duration.
A new study of acute effects in volunteers suggests that hydrogen peroxide is slightly irritating at 2.2 ml/m3, but not at 0.5 ml/m3. These findings support all previously described results of inhalation studies in workers or volunteers.
Based on the NOAEC established for humans, the MAK value of 0.5 ml/m3 is retained.
Peak Limitation Category I and the excursion factor of 1 are retained as there are no new data.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of hydrogen peroxide [7722‐84‐1] as new inhalation studies are available.
Hydrogen peroxide is an irritant to the respiratory tract and the eyes.
In a 90‐day inhalation study in the rat a NOAEC of 7 ml/m3 was determined, which confirms the previous 28‐day inhalation study and proves that the effects at the respiratory tract do not increase with exposure duration.
A new study of acute effects in volunteers suggests that hydrogen peroxide is slightly irritating at 2.2 ml/m3, but not at 0.5 ml/m3. These findings support all previously described results of inhalation studies in workers or volunteers.
Based on the NOAEC established for humans, the MAK value of 0.5 ml/m3 is retained.
Peak Limitation Category I and the excursion factor of 1 are retained as there are no new data.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:30 January 2019
Deposited On:21 Nov 2019 15:14
Last Modified:29 Jul 2020 11:45
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb772284d0066

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