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Zirkoniumdioxid (alveolengängige Fraktion) [MAK value documentation in German language, 2019]


Hartwig, A; MAK Commission; Arand, Michael; et al (2019). Zirkoniumdioxid (alveolengängige Fraktion) [MAK value documentation in German language, 2019]. The MAK Collection for Occupational Health and Safety, 4(3):1577-1590.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated zirconium dioxide [1314‐23‐4]. Zirconium dioxide is a biopersistent granular dust. Therefore, the respirable fraction of zirconium dioxide dust is classified in Carcinogen Category 4 and a maximum concentration at the workplace (MAK value) of 0.3 mg/m3 × material density is established for the respirable fraction in analogy to the other biopersistent granular dusts. Additionally, this fraction is classified in Peak Limitation Category II with an excursion factor of 8. As zirconium dioxide is not systemically distributed and accumulates only locally in the lungs, no developmental toxicity is expected to occur at the MAK value of 0.3 mg/m3 × material density (respirable fraction). Accordingly, zirconium dioxide is classified in Pregnancy Risk Group C. Zirconium dioxide is not a sensitizer and is not taken up via the skin in toxicologically relevant amounts.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated zirconium dioxide [1314‐23‐4]. Zirconium dioxide is a biopersistent granular dust. Therefore, the respirable fraction of zirconium dioxide dust is classified in Carcinogen Category 4 and a maximum concentration at the workplace (MAK value) of 0.3 mg/m3 × material density is established for the respirable fraction in analogy to the other biopersistent granular dusts. Additionally, this fraction is classified in Peak Limitation Category II with an excursion factor of 8. As zirconium dioxide is not systemically distributed and accumulates only locally in the lungs, no developmental toxicity is expected to occur at the MAK value of 0.3 mg/m3 × material density (respirable fraction). Accordingly, zirconium dioxide is classified in Pregnancy Risk Group C. Zirconium dioxide is not a sensitizer and is not taken up via the skin in toxicologically relevant amounts.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:1 August 2019
Deposited On:21 Nov 2019 14:33
Last Modified:29 Jul 2020 11:45
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb131423d0067

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