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Axial differences in endocytosis along the kidney proximal tubule


Polesel, Marcello; Hall, Andrew M (2019). Axial differences in endocytosis along the kidney proximal tubule. American Journal of Physiology. Renal, Fluid and Electrolyte Physiology, 317(6):F1526-F1530.

Abstract

The proximal tubule (PT) reabsorbs filtered proteins via receptor mediated endocytosis to prevent energetically inefficient wasting in the urine. Recent intravital imaging studies have suggested that protein reabsorption occurs in early (S1) segments, which have a very high capacity. In contrast, uptake of fluid phase substrates also occurs in distal (S2) segments. In this article, we will review these findings and their implications for understanding integrated proximal tubular function, patterns of damage caused by endocytosed toxins, and the origins of proteinuria. We will also discuss whether compensatory downstream increases in protein uptake might occur in disease states, and the environmental factors that could drive these changes.

Abstract

The proximal tubule (PT) reabsorbs filtered proteins via receptor mediated endocytosis to prevent energetically inefficient wasting in the urine. Recent intravital imaging studies have suggested that protein reabsorption occurs in early (S1) segments, which have a very high capacity. In contrast, uptake of fluid phase substrates also occurs in distal (S2) segments. In this article, we will review these findings and their implications for understanding integrated proximal tubular function, patterns of damage caused by endocytosed toxins, and the origins of proteinuria. We will also discuss whether compensatory downstream increases in protein uptake might occur in disease states, and the environmental factors that could drive these changes.

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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Health Sciences > Urology
Uncontrolled Keywords:Urology, Physiology
Language:English
Date:1 December 2019
Deposited On:15 Nov 2019 15:12
Last Modified:28 Oct 2020 01:00
Publisher:American Physiological Society
ISSN:1522-1466
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1152/ajprenal.00459.2019
PubMed ID:31657246

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