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New insights and perspectives on the genetics of obsessive-compulsive disorder


Zai, Gwyneth; Barta, Csaba; Cath, Danielle; Eapen, Valsamma; Geller, Daniel; Grünblatt, Edna (2019). New insights and perspectives on the genetics of obsessive-compulsive disorder. Psychiatric Genetics, 29(5):142-151.

Abstract

Psychiatric genetic research has exploded in search of polygenic risk factors over the past decade, but because of the complexity and heterogeneity of mental illnesses, using the current understanding of the genome has not reached the conclusion of finding a cause for psychiatric disorders. Obsessive-compulsive disorder is a relatively common and often debilitating neuropsychiatric disorder that has not been the primary focus in psychiatric research. Clinicians and researchers who have dedicated to investigate the genetics of obsessive-compulsive disorder have detected a strong genetic involvement. This review will provide an update and a new perspective on the current understanding of the genetics of obsessive-compulsive disorder, which includes epidemiological data, family and twins studies, candidate gene studies, genome-wide association studies, copy-number variants, imaging genetics, epigenetics, and gene-environment interaction.

Abstract

Psychiatric genetic research has exploded in search of polygenic risk factors over the past decade, but because of the complexity and heterogeneity of mental illnesses, using the current understanding of the genome has not reached the conclusion of finding a cause for psychiatric disorders. Obsessive-compulsive disorder is a relatively common and often debilitating neuropsychiatric disorder that has not been the primary focus in psychiatric research. Clinicians and researchers who have dedicated to investigate the genetics of obsessive-compulsive disorder have detected a strong genetic involvement. This review will provide an update and a new perspective on the current understanding of the genetics of obsessive-compulsive disorder, which includes epidemiological data, family and twins studies, candidate gene studies, genome-wide association studies, copy-number variants, imaging genetics, epigenetics, and gene-environment interaction.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Department of Child and Adolescent Psychiatry
04 Faculty of Medicine > Neuroscience Center Zurich
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Genetics
Health Sciences > Genetics (clinical)
Health Sciences > Psychiatry and Mental Health
Life Sciences > Biological Psychiatry
Uncontrolled Keywords:Genetics(clinical), Genetics, Biological Psychiatry, Psychiatry and Mental health
Language:English
Date:1 October 2019
Deposited On:22 Nov 2019 15:43
Last Modified:29 Jul 2020 11:50
Publisher:Lippincott Williams & Wilkins
ISSN:0955-8829
OA Status:Closed
Publisher DOI:https://doi.org/10.1097/ypg.0000000000000230
PubMed ID:31464995

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Content: Published Version
Language: English
Filetype: PDF - Registered users only until 1 November 2020
Size: 213kB
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Embargo till: 2020-11-01