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Chapter 18 - Stress and its effects across generations


Engmann, Olivia; Mansuy, Isabelle M (2020). Chapter 18 - Stress and its effects across generations. In: Chen, Alon. Stress Resilience Molecular and Behavioral Aspects. London: Elsevier, 269-290.

Abstract

Stress affects the risk for psychiatric illnesses. Emerging research shows that stress not only alters disease risk within the lifetime of an individual but also modifies molecular and behavioral responses across generations. As familial predisposition can only in part be explained by genetic factors for the majority of psychiatric ailments, epigenetics is a promising candidate for intergenerational stress effects. Here, we provide evidence from animal models and human studies for the epigenetic inheritance of stress effects. In this chapter, we discuss factors that may contribute to the controversy of this novel research field, including the importance of critical periods, stressor type, and other nongenetic modes of transmission. Although currently human studies on epigenetic inheritance are rare, more research in this field will advance our understanding of human disease and may provide a new dimension to personalized therapy.

Abstract

Stress affects the risk for psychiatric illnesses. Emerging research shows that stress not only alters disease risk within the lifetime of an individual but also modifies molecular and behavioral responses across generations. As familial predisposition can only in part be explained by genetic factors for the majority of psychiatric ailments, epigenetics is a promising candidate for intergenerational stress effects. Here, we provide evidence from animal models and human studies for the epigenetic inheritance of stress effects. In this chapter, we discuss factors that may contribute to the controversy of this novel research field, including the importance of critical periods, stressor type, and other nongenetic modes of transmission. Although currently human studies on epigenetic inheritance are rare, more research in this field will advance our understanding of human disease and may provide a new dimension to personalized therapy.

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Additional indexing

Item Type:Book Section, not_refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords:Epigenetics: Inheritance; Intergenerational transmission; Stress; Trauma
Language:English
Date:1 January 2020
Deposited On:05 Dec 2019 10:43
Last Modified:09 Dec 2019 08:55
Publisher:Elsevier
ISBN:9780128139837
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/b978-0-12-813983-7.00018-5
Official URL:https://www.sciencedirect.com/book/9780128139837/stress-resilience

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Embargo till: 2021-12-09
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