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Now a Nobel gas: oxygen


Fandrey, Joachim; Schödel, Johannes; Eckardt, Kai-Uwe; Katschinski, Dörthe M; Wenger, Roland H (2019). Now a Nobel gas: oxygen. Pflügers Archiv : European Journal of Physiology, (471):1343-1358.

Abstract

The recent bestowal of the Nobel Prize 2019 in Physiology or Medicine to Gregg L. Semenza, Sir Peter J. Ratcliffe, and William G. Kaelin Jr. celebrates a series of remarkable discoveries that span from the physiological research question on how oxygen deficiency (hypoxia) induces the red blood cell forming hormone erythropoietin (Epo) to the first clinical application of a novel family of Epo-inducing drugs to treat patients suffering from renal anemia. This review looks back at the most important findings made by the three Nobel laureates, highlights current research trends, and sheds an eye on future perspectives of hypoxia research, including emerging and potential clinical applications.

Abstract

The recent bestowal of the Nobel Prize 2019 in Physiology or Medicine to Gregg L. Semenza, Sir Peter J. Ratcliffe, and William G. Kaelin Jr. celebrates a series of remarkable discoveries that span from the physiological research question on how oxygen deficiency (hypoxia) induces the red blood cell forming hormone erythropoietin (Epo) to the first clinical application of a novel family of Epo-inducing drugs to treat patients suffering from renal anemia. This review looks back at the most important findings made by the three Nobel laureates, highlights current research trends, and sheds an eye on future perspectives of hypoxia research, including emerging and potential clinical applications.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords:Clinical Biochemistry, Physiology (medical), Physiology
Language:English
Date:22 November 2019
Deposited On:17 Dec 2019 14:33
Last Modified:17 Dec 2019 14:33
Publisher:Springer
ISSN:0031-6768
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s00424-019-02334-8
PubMed ID:31754831
Project Information:
  • : FunderSNSF
  • : Grant ID310030_184813
  • : Project TitleSingle cell variability of hypoxia-inducible gene expression

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