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Distinct mechanisms of hypoglycaemia in patients with somatostatin-secreting neuroendocrine tumours


Wiesli, Peter; Pavlicek, Vojtech; Brändle, Michael; Pfammatter, Thomas; Perren, Aurel; Schmid, Christoph (2019). Distinct mechanisms of hypoglycaemia in patients with somatostatin-secreting neuroendocrine tumours. Endocrinology, diabetes and metabolism, 2(4):e00083.

Abstract

Introduction
Somatostatin-secreting neuroendocrine tumours may present with diabetes, cholelithiasis and steatorrhoea. In addition, hypoglycaemia has been associated with somatostatinomas. However, the mechanism of hypoglycaemia in patients with somatostatinomas has not been well characterized.
Methods
We describe two patients with recurrent neuroglycopenic episodes caused by somatostatin-secreting neuroendocrine tumours in the liver, detected by abdominal CTs and whole-body octreotide scintigraphy scans and confirmed by biopsy.
Results
Pancreatic islet hyperplasia and co-secretion of insulin (in addition to somatostatin) from tumour cells, respectively, have been characterized as completely distinct mechanisms of hypoglycaemia at both the functional and morphological levels in these two patients.
Conclusions
Hypoglycaemia may be caused by different mechanisms in patients with somatostatinomas.

Abstract

Introduction
Somatostatin-secreting neuroendocrine tumours may present with diabetes, cholelithiasis and steatorrhoea. In addition, hypoglycaemia has been associated with somatostatinomas. However, the mechanism of hypoglycaemia in patients with somatostatinomas has not been well characterized.
Methods
We describe two patients with recurrent neuroglycopenic episodes caused by somatostatin-secreting neuroendocrine tumours in the liver, detected by abdominal CTs and whole-body octreotide scintigraphy scans and confirmed by biopsy.
Results
Pancreatic islet hyperplasia and co-secretion of insulin (in addition to somatostatin) from tumour cells, respectively, have been characterized as completely distinct mechanisms of hypoglycaemia at both the functional and morphological levels in these two patients.
Conclusions
Hypoglycaemia may be caused by different mechanisms in patients with somatostatinomas.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:October 2019
Deposited On:06 Jan 2020 11:24
Last Modified:29 Jul 2020 12:04
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:2398-9238
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/edm2.83
PubMed ID:31592116

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