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Magnetoelectric 3D scaffolds for enhanced bone cell proliferation


Mushtaq, Fajer; Torlakcik, Harun; Vallmajo-Martin, Queralt; Siringil, Erdem Can; Zhang, Jianhua; Röhrig, Christian; Shen, Yang; Yu, Yingchuan; Chen, Xiang-Zhong; Müller, Ralph; Nelson, Bradley J; Pané, Salvador (2019). Magnetoelectric 3D scaffolds for enhanced bone cell proliferation. Applied Materials Today, 16:290-300.

Abstract

Regulation of cellular functions by an exogenous and non-invasive approach has the means of revolutionizing the field of tissue engineering. In this direction, use of electric fields has garnered significant interest due to its positive influence on cell adhesion, proliferation, and differentiation. Recently, this has been achieved by placing electrodes in direct contact with cells, or through a non-contact approach by inducing deformation of piezoelectric membranes. In this work, we have developed 3D magnetoelectric inverse opal scaffolds that can generate localized electric fields upon the application of magnetic fields. These scaffolds were composed of biodegradable poly(l-lactic acid), and cobalt ferrite@bismuth ferrite magnetoelectric nanoparticles and were designed to mimic the natural micro-environment of cancellous bone by endowing them with piezoelectric properties and porosity. The effect of magnetic field induced electric stimulation on the proliferation of human-derived MG63 osteoblast cells, a model for primary osteoblast cells, was investigated on 2D membranes and 3D scaffolds by applying a magnetic field of 13 mT at 1.1 kHz. During this study, a 134% increase in cell proliferation was achieved on stimulated 3D scaffolds in comparison to non-stimulated ones, and in case of 2D membranes, we have obtained an increase of 43% of stimulated 2D membranes in comparison to non-stimulated ones. These findings showcase the importance of designing scaffolds with 3D characteristics that provide a suitable micro-environment for host cells. The results obtained from this work further demonstrate the beneficial influence that the magnetoelectric effect has on regulating cellular functions and draws light on the possibility of exploiting this effect for tissue engineering and regenerative medicine in the future.

Abstract

Regulation of cellular functions by an exogenous and non-invasive approach has the means of revolutionizing the field of tissue engineering. In this direction, use of electric fields has garnered significant interest due to its positive influence on cell adhesion, proliferation, and differentiation. Recently, this has been achieved by placing electrodes in direct contact with cells, or through a non-contact approach by inducing deformation of piezoelectric membranes. In this work, we have developed 3D magnetoelectric inverse opal scaffolds that can generate localized electric fields upon the application of magnetic fields. These scaffolds were composed of biodegradable poly(l-lactic acid), and cobalt ferrite@bismuth ferrite magnetoelectric nanoparticles and were designed to mimic the natural micro-environment of cancellous bone by endowing them with piezoelectric properties and porosity. The effect of magnetic field induced electric stimulation on the proliferation of human-derived MG63 osteoblast cells, a model for primary osteoblast cells, was investigated on 2D membranes and 3D scaffolds by applying a magnetic field of 13 mT at 1.1 kHz. During this study, a 134% increase in cell proliferation was achieved on stimulated 3D scaffolds in comparison to non-stimulated ones, and in case of 2D membranes, we have obtained an increase of 43% of stimulated 2D membranes in comparison to non-stimulated ones. These findings showcase the importance of designing scaffolds with 3D characteristics that provide a suitable micro-environment for host cells. The results obtained from this work further demonstrate the beneficial influence that the magnetoelectric effect has on regulating cellular functions and draws light on the possibility of exploiting this effect for tissue engineering and regenerative medicine in the future.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > General Materials Science
Uncontrolled Keywords:General Materials Science
Language:English
Date:1 September 2019
Deposited On:07 Jan 2020 10:30
Last Modified:29 Jul 2020 12:07
Publisher:Elsevier
ISSN:2352-9407
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.apmt.2019.06.004
Project Information:
  • : FunderFP7
  • : Grant ID336456
  • : Project TitleELECTROCHEMBOTS - MAGNETOELECTRIC CHEMONANOROBOTICS FOR CHEMICAL AND BIOMEDICAL APPLICATIONS

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