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The experience-dependent increase in deep sleep activity is reduced in children with attention-deficit/hyperactivity disorder


Furrer, Melanie; Ringli, Maya; Kurth, Salome; Brandeis, Daniel; Jenni, Oskar G; Huber, Reto (2020). The experience-dependent increase in deep sleep activity is reduced in children with attention-deficit/hyperactivity disorder. Sleep Medicine, 75:50-53.

Abstract

Objective/Background
Learning of a visuomotor adaptation task during wakefulness leads to a local increase in slow-wave activity (SWA, EEG power between 1 and 4.5 Hz) during subsequent deep sleep. Here, we examined this relationship between learning and SWA in children with attention-deficit/hyperactivity disorder (ADHD).

Patients/Methods
Participants were 15 children with ADHD (9.7 – 14.8 y, one female) and 15 age-matched healthy controls (9.6 – 15.7 y, three female). After the completion of a visuomotor adaptation task in the evening, participants underwent an all-night high-density (HD, 128 electrodes) sleep-EEG measurement.

Results
Healthy control children showed the expected right-parietal increase in sleep SWA after visuomotor learning. Despite no difference in visuomotor learning, the local up-regulation during sleep was significantly reduced in ADHD patients compared to healthy controls.

Conclusions
Our results indicate that the local, experience-dependent regulation of SWA is different in ADHD patients. Because the customarily observed heightened regulation in children was related to sensitive period maturation, ADHD patients may lack certain sensitive periods or show a developmental delay.

Abstract

Objective/Background
Learning of a visuomotor adaptation task during wakefulness leads to a local increase in slow-wave activity (SWA, EEG power between 1 and 4.5 Hz) during subsequent deep sleep. Here, we examined this relationship between learning and SWA in children with attention-deficit/hyperactivity disorder (ADHD).

Patients/Methods
Participants were 15 children with ADHD (9.7 – 14.8 y, one female) and 15 age-matched healthy controls (9.6 – 15.7 y, three female). After the completion of a visuomotor adaptation task in the evening, participants underwent an all-night high-density (HD, 128 electrodes) sleep-EEG measurement.

Results
Healthy control children showed the expected right-parietal increase in sleep SWA after visuomotor learning. Despite no difference in visuomotor learning, the local up-regulation during sleep was significantly reduced in ADHD patients compared to healthy controls.

Conclusions
Our results indicate that the local, experience-dependent regulation of SWA is different in ADHD patients. Because the customarily observed heightened regulation in children was related to sensitive period maturation, ADHD patients may lack certain sensitive periods or show a developmental delay.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Department of Child and Adolescent Psychiatry
04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:General Medicine
Language:English
Date:1 November 2020
Deposited On:07 Jan 2020 10:27
Last Modified:04 Oct 2020 00:00
Publisher:Elsevier
ISSN:1389-9457
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.sleep.2019.09.018
Project Information:
  • : FunderSNSF
  • : Grant IDPP0033-114923
  • : Project TitleSleep and brain plasticity during development

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