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Does Neuronal Activity Promote Glioma Progression?


Wirsching, Hans-Georg; Weller, Michael (2020). Does Neuronal Activity Promote Glioma Progression? Trends in Cancer, 6(1):1-3.

Abstract

Excessive glutamate release by glioma cells induces pharmacologically accessible neuronal hyperexcitation, including epilepsy. Two recent reports by Venkataramani et al. and Venkatesh et al. suggest that neuronal hyperexcitation stimulates bona fide glutamatergic synapses on glioma cells. Ionotropic glutamate receptors activate intercellular calcium signaling networks to orchestrate glioma cell growth and invasion, presumably by facilitating oncogenic signaling cascades and cytoskeletal remodeling.

Abstract

Excessive glutamate release by glioma cells induces pharmacologically accessible neuronal hyperexcitation, including epilepsy. Two recent reports by Venkataramani et al. and Venkatesh et al. suggest that neuronal hyperexcitation stimulates bona fide glutamatergic synapses on glioma cells. Ionotropic glutamate receptors activate intercellular calcium signaling networks to orchestrate glioma cell growth and invasion, presumably by facilitating oncogenic signaling cascades and cytoskeletal remodeling.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Life Sciences > Cancer Research
Language:English
Date:1 January 2020
Deposited On:08 Jan 2020 10:13
Last Modified:29 Jul 2020 12:20
Publisher:Elsevier
ISSN:2405-8033
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.trecan.2019.11.002

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Content: Accepted Version
Filetype: PDF - Registered users only until 7 December 2021
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Embargo till: 2021-12-07