2D oxide quasicrystals (OQCs) are recently discovered aperiodic, but well‐ordered oxide interfaces. In this topical review, an introduction to these new thin‐film systems is given. The concept of quasicrystals and their approximants is explained for BaTiO3‐ and SrTiO3‐derived OQCs and related periodic structures in these 2D oxides. In situ microscopy unravels the high‐temperature formation process of OQCs on Pt(111). The dodecagonal structure is discussed regarding tiling statistics and tiling decoration based on the results of atomically resolved scanning tunneling microscopy and various diffraction techniques. In addition, angle‐resolved ultraviolet photoemission spectroscopy and X‐ray photoelectron spectroscopy results prove a metallic character of the 2D oxide.