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Method for the determination of epichlorohydrin in workplace air using gas chromatography after thermal desorption [Air monitoring methods, 2019]


Hartwig, A; MAK Commission; Arand, Michael; et al (2019). Method for the determination of epichlorohydrin in workplace air using gas chromatography after thermal desorption [Air monitoring methods, 2019]. The MAK Collection for Occupational Health and Safety, 4(4):2362-2374.

Abstract

This analytical method is a validated measurement procedure for the determination of epichlorohydrin [106‐89‐8] in workplace air averaged over the sampling period after personal or stationary sampling. Sampling is performed by drawing a defined volume of air through an adsorption tube filled with Tenax TA using a suitable flow‐regulated pump. The flow rate is set to 20 mL/min with a recommended air sample volume of 1.2 L (which corresponds to a sampling period of 60 min). After thermal desorption at 280 °C the sample is analysed by means of GC with a flame ionisation detector (FID). The quantitative determination is based on a calibration function obtained by means of a multiple‐point calibration. The relative limit of quantification (LOQ) is 0.39 mg/m3 epichlorohydrin for an air sample volume of 1.2 L. The mean recovery was 95% and the expanded uncertainty for epichlorohydrin was 16.1% over the entire measurement range.

Joint Publication of the Analytical Subcommittee of the Chemistry Board of Experts of the Expert Committee Raw Materials and Chemical Industry of the German Social Accident Insurance and the working group “Air Analyses” of the Permanent Senate Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area

Abstract

This analytical method is a validated measurement procedure for the determination of epichlorohydrin [106‐89‐8] in workplace air averaged over the sampling period after personal or stationary sampling. Sampling is performed by drawing a defined volume of air through an adsorption tube filled with Tenax TA using a suitable flow‐regulated pump. The flow rate is set to 20 mL/min with a recommended air sample volume of 1.2 L (which corresponds to a sampling period of 60 min). After thermal desorption at 280 °C the sample is analysed by means of GC with a flame ionisation detector (FID). The quantitative determination is based on a calibration function obtained by means of a multiple‐point calibration. The relative limit of quantification (LOQ) is 0.39 mg/m3 epichlorohydrin for an air sample volume of 1.2 L. The mean recovery was 95% and the expanded uncertainty for epichlorohydrin was 16.1% over the entire measurement range.

Joint Publication of the Analytical Subcommittee of the Chemistry Board of Experts of the Expert Committee Raw Materials and Chemical Industry of the German Social Accident Insurance and the working group “Air Analyses” of the Permanent Senate Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:13 November 2019
Deposited On:04 Feb 2020 15:27
Last Modified:04 Feb 2020 15:29
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.am10689e2019

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