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Method for the determination of 1,3‐butadiene in workplace air using headspace GC [Air monitoring methods, 2019]


Hartwig, A; MAK Commission; Arand, Michael; et al (2019). Method for the determination of 1,3‐butadiene in workplace air using headspace GC [Air monitoring methods, 2019]. The MAK Collection for Occupational Health and Safety, 4(4):2353-2361.

Abstract

This analytical method is a validated measurement procedure for the determination of 1,3‐butadiene [106‐99‐0] in workplace air averaged over the sampling period after personal or stationary sampling. Sampling is performed by drawing a defined volume of air through a charcoal tube using a suitable flow‐regulated pump. The flow rate is set to 40 mL/min with a recommended air sample volume of 20 L. The collected 1,3‐butadiene is desorbed with a mixture of benzyl alcohol/dimethyl sulfoxide/water (90+5+5 v:v) and then analysed by means of headspace‐GC and a mass selective detector (MSD). The quantitative evaluation is based on a calibration function obtained by means of a multiple‐point calibration using dichloromethane‐D2 as internal standard. Based on the resulting peak areas the respective mass of 1,3‐butadiene can be obtained from the calibration function. The absolute limit of quantification (LOQ) is 0.5 µg for 1,3‐butadiene deposited on a charcoal tube. The mean recovery was 84% and the expanded uncertainty for 1,3‐butadiene was between 21 and 23%.

Joint Publication of the Analytical Subcommittee of the Chemistry Board of Experts of the Expert Committee Raw Materials and Chemical Industry of the German Social Accident Insurance and the working group “Air Analyses” of the Permanent Senate Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area.

Abstract

This analytical method is a validated measurement procedure for the determination of 1,3‐butadiene [106‐99‐0] in workplace air averaged over the sampling period after personal or stationary sampling. Sampling is performed by drawing a defined volume of air through a charcoal tube using a suitable flow‐regulated pump. The flow rate is set to 40 mL/min with a recommended air sample volume of 20 L. The collected 1,3‐butadiene is desorbed with a mixture of benzyl alcohol/dimethyl sulfoxide/water (90+5+5 v:v) and then analysed by means of headspace‐GC and a mass selective detector (MSD). The quantitative evaluation is based on a calibration function obtained by means of a multiple‐point calibration using dichloromethane‐D2 as internal standard. Based on the resulting peak areas the respective mass of 1,3‐butadiene can be obtained from the calibration function. The absolute limit of quantification (LOQ) is 0.5 µg for 1,3‐butadiene deposited on a charcoal tube. The mean recovery was 84% and the expanded uncertainty for 1,3‐butadiene was between 21 and 23%.

Joint Publication of the Analytical Subcommittee of the Chemistry Board of Experts of the Expert Committee Raw Materials and Chemical Industry of the German Social Accident Insurance and the working group “Air Analyses” of the Permanent Senate Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:13 November 2019
Deposited On:04 Feb 2020 14:56
Last Modified:04 Feb 2020 15:09
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.am10699e2019

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