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Ethylamine [MAK Value Documentation, 2019]


Hartwig, A; MAK Commission; Arand, Michael; et al (2019). Ethylamine [MAK Value Documentation, 2019]. The MAK Collection for Occupational Health and Safety, 4(4):2045-2053.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated ethylamine [75‐04‐7], considering all toxicological endpoints.

The critical effect is irritation of the nasal epithelium of rats with a NOAEC of 100 ml/m3 in a 24‐week inhalation study. The maximum concentration at the workplace (MAK value) for ethylamine is derived by using additional data of the structurally related diethylamine. For diethylamine a MAK value of 2 ml/m3 was derived based on a two‐year study in rats with a NOAEC of 16 ml/m3 for irritation of the nasal epithelium and a study in humans with a LOAEC of 10 ml/m3 for sensory irritation. As the inhalation toxicity of ethylamine is lower than that of diethylamine, the previous MAK value for ethylamine of 5 ml/m3 is retained. As the local effect is critical, ethylamine remains classified in Peak Limitation Category I. The excursion factor of 2 and the momentary value (concentration which must not be exceeded at any time) of 10 ml/m3 are retained.

There are no developmental toxicity studies and ethylamine remains assigned to Pregnancy Risk Group D. Ethylamine is not genotoxic in vitro, data on genotoxicity in vivo and carcinogenicity are lacking. There is, however, no corresponding structural alert. There are no data on sensitization. According to skin absorption models, percutaneous absorption does not contribute significantly to systemic toxicity.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated ethylamine [75‐04‐7], considering all toxicological endpoints.

The critical effect is irritation of the nasal epithelium of rats with a NOAEC of 100 ml/m3 in a 24‐week inhalation study. The maximum concentration at the workplace (MAK value) for ethylamine is derived by using additional data of the structurally related diethylamine. For diethylamine a MAK value of 2 ml/m3 was derived based on a two‐year study in rats with a NOAEC of 16 ml/m3 for irritation of the nasal epithelium and a study in humans with a LOAEC of 10 ml/m3 for sensory irritation. As the inhalation toxicity of ethylamine is lower than that of diethylamine, the previous MAK value for ethylamine of 5 ml/m3 is retained. As the local effect is critical, ethylamine remains classified in Peak Limitation Category I. The excursion factor of 2 and the momentary value (concentration which must not be exceeded at any time) of 10 ml/m3 are retained.

There are no developmental toxicity studies and ethylamine remains assigned to Pregnancy Risk Group D. Ethylamine is not genotoxic in vitro, data on genotoxicity in vivo and carcinogenicity are lacking. There is, however, no corresponding structural alert. There are no data on sensitization. According to skin absorption models, percutaneous absorption does not contribute significantly to systemic toxicity.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:13 November 2019
Deposited On:04 Feb 2020 15:21
Last Modified:04 Feb 2020 15:21
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb7504e6619

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