Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Osteoconductive Lattice Microarchitecture for Optimized Bone Regeneration

De Wild, Michael; Ghayor, Chafik; Zimmermann, Simon; Rüegg, Jasmine; Nicholls, Flora; Schuler, Felix; Chen, Tse-Hsiang; Weber, Franz E (2019). Osteoconductive Lattice Microarchitecture for Optimized Bone Regeneration. 3D Printing and Additive Manufacturing, 6(1):40-49.

Abstract

Selective laser melting (SLM) is one methodology to realize additive manufacturing and is mainly used to join metal powder in a layer-by-layer manner to produce a solid three-dimensional (3D) object. For bone tissue engineering purposes, scaffolds can readily be designed as 3D data model and realized with titanium known for its excellent osseointegration behavior. The microarchitecture, that is, design with submillimeter features, of additively manufactured scaffolds is in many cases a lattice structure. This study aimed to apply SLM that allows a high degree of microarchitectural freedom to generate lattice structures and to determine the optimal distance between rods and the optimal diameter of rods for osteoconduction (bone ingrowth into scaffolds) and bone regeneration. For the biological readout, diverse SLM-fabricated titanium implants were placed in the calvarium of rabbits and new bone formation and defect bridging were determined after 4 weeks of healing. The results from the middle section of the defects show that with a lattice microarchitecture, the optimal distance between titanium rods is around 0.8 mm and the optimal rod dimension is between 0.3 and 0.4 mm to optimize defect bridging and bone regeneration.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic of Cranio-Maxillofacial Surgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > Materials Science (miscellaneous)
Physical Sciences > Industrial and Manufacturing Engineering
Uncontrolled Keywords:Industrial and Manufacturing Engineering, Materials Science (miscellaneous)
Language:English
Date:20 February 2019
Deposited On:18 Dec 2019 14:56
Last Modified:22 Oct 2024 01:39
Publisher:Mary Ann Liebert
ISSN:2329-7662
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1089/3dp.2017.0129
Download PDF  'Osteoconductive Lattice Microarchitecture for Optimized Bone Regeneration'.
Preview
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
31 citations in Web of Science®
32 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

60 downloads since deposited on 18 Dec 2019
8 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications