Header

UZH-Logo

Maintenance Infos

Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded


Samaratunga, Hemamali; Delahunt, Brett; Egevad, Lars; Srigley, John R; et al; Moch, Holger (2019). Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded. Pathology:5.

Abstract

Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.

Abstract

Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.

Statistics

Citations

Dimensions.ai Metrics
10 citations in Web of Science®
11 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pathology and Forensic Medicine
Language:English
Date:14 December 2019
Deposited On:15 Jan 2020 14:11
Last Modified:29 Jul 2020 12:38
Publisher:Elsevier
ISSN:0031-3025
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.pathol.2019.11.001
PubMed ID:31843189

Download

Full text not available from this repository.
View at publisher

Get full-text in a library