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Effects of short- and long-term exposures to particulate matter on inflammatory marker levels in the general population


Tsai, Dai-Hua; Riediker, Michael; Berchet, Antoine; Paccaud, Fred; Waeber, Gerard; Vollenweider, Peter; Bochud, Murielle (2019). Effects of short- and long-term exposures to particulate matter on inflammatory marker levels in the general population. Environmental Science and Pollution Research International, 26(19):19697-19704.

Abstract

The effect of particulate matter (PM) on health increases with exposure duration but the change from short to longer term is not well studied. We examined the exposure to PM smaller 10 μm (PM10) from short to longer duration and their associations with levels of inflammatory markers in the population-based CoLaus cohort in Lausanne, Switzerland. Baseline and follow-up CoLaus data were used to study the associations between PM10 exposure and inflammatory markers, including the high-sensitivity C-reactive protein (CRP), as well as interleukin 1-beta (IL-1β), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-α) using mixed models. Exposure was determined for each participant’s home address from hourly air quality simulations at a 5-m resolution. Short-term exposure intervals were 1 day, 1 week, and 1 month prior to the hospital visit (blood withdrawal); long-term exposure intervals were 3 and 6 months prior to the visit. In most time windows, IL-6, IL-1β, and TNF-α were positively associated with PM10. No significant associations were identified for CRP. Adjusted associations with long-term exposures were stronger and more significant than those for short-term exposures. In stratified models, gender, age, smoking status, and hypertension only led to small modifications in effect estimates, though a few of the estimates for IL-6 and TNF-α became non-significant. In this general adult cohort exposed to relatively low average PM10 levels, clear associations with markers of systemic inflammation were observed. Longer duration of elevated exposure was associated with an exacerbated inflammatory response. This may partially explain the elevated disease risk observed with chronic PM10 exposure. It also suggests that reducing prolonged episodes of high PM exposure may be a strategy to reduce inflammatory risk.

Abstract

The effect of particulate matter (PM) on health increases with exposure duration but the change from short to longer term is not well studied. We examined the exposure to PM smaller 10 μm (PM10) from short to longer duration and their associations with levels of inflammatory markers in the population-based CoLaus cohort in Lausanne, Switzerland. Baseline and follow-up CoLaus data were used to study the associations between PM10 exposure and inflammatory markers, including the high-sensitivity C-reactive protein (CRP), as well as interleukin 1-beta (IL-1β), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-α) using mixed models. Exposure was determined for each participant’s home address from hourly air quality simulations at a 5-m resolution. Short-term exposure intervals were 1 day, 1 week, and 1 month prior to the hospital visit (blood withdrawal); long-term exposure intervals were 3 and 6 months prior to the visit. In most time windows, IL-6, IL-1β, and TNF-α were positively associated with PM10. No significant associations were identified for CRP. Adjusted associations with long-term exposures were stronger and more significant than those for short-term exposures. In stratified models, gender, age, smoking status, and hypertension only led to small modifications in effect estimates, though a few of the estimates for IL-6 and TNF-α became non-significant. In this general adult cohort exposed to relatively low average PM10 levels, clear associations with markers of systemic inflammation were observed. Longer duration of elevated exposure was associated with an exacerbated inflammatory response. This may partially explain the elevated disease risk observed with chronic PM10 exposure. It also suggests that reducing prolonged episodes of high PM exposure may be a strategy to reduce inflammatory risk.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Department of Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > Environmental Chemistry
Physical Sciences > Pollution
Physical Sciences > Health, Toxicology and Mutagenesis
Uncontrolled Keywords:Pollution, Health, Toxicology and Mutagenesis, Environmental Chemistry, General Medicine
Language:English
Date:1 July 2019
Deposited On:16 Jan 2020 09:07
Last Modified:29 Jul 2020 12:42
Publisher:Springer
ISSN:0944-1344
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s11356-019-05194-y
PubMed ID:31079306
Project Information:
  • : FunderSNSF
  • : Grant ID33CSC0-122661
  • : Project TitleCardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study
  • : FunderSNSF
  • : Grant ID33CS30_139468
  • : Project TitleCardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study
  • : FunderSNSF
  • : Grant ID33CS30_148401
  • : Project TitleCardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study
  • : FunderNano-Tera.ch
  • : Grant IDRTD2013: 20NA20_150956
  • : Project Title
  • : Project Websitehttp://www.nanotera.ch

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