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Dopaminergic D1 Receptor Stimulation Affects Effort and Risk Preferences

Soutschek, Alexander; Gvozdanovic, Geraldine; Kozak, Rouba; Duvvuri, Sridhar; de Martinis, Nicholas; Harel, Brian; Gray, David L; Fehr, Ernst; Jetter, Alexander; Tobler, Philippe N (2020). Dopaminergic D1 Receptor Stimulation Affects Effort and Risk Preferences. Biological Psychiatry, 87(7):678-685.

Abstract

BACKGROUND:
Activation of D1 receptors has been related to successful goal-directed behavior, but it remains unclear whether D1 receptor activation causally tips the balance of weighing costs and benefits in humans. Here, we tested the impact of pharmacologically stimulated D1 receptors on sensitivity to risk, delay, and effort costs in economic choice and investigated whether D1 receptor stimulation would bias preferences toward options with increased costs in a cost-specific manner.

METHODS:
In a randomized, double-blind, placebo-controlled, parallel-group phase 1 study, 120 healthy young volunteers received either placebo or 1 of 3 doses (6 mg, 15 mg, or 30 mg) of a novel, selective D1 agonist (PF-06412562). After drug administration, participants performed decision tasks measuring their preferences for risky, delayed, and effortful outcomes.

RESULTS:
Higher doses of the D1 agonist increased the willingness to exert physical effort for reward as well as reduced the preference for risky outcomes. We observed no effects on preferences for delayed rewards.

CONCLUSIONS:
The current results provide evidence that D1 receptor stimulation causally affects core aspects of cost-benefit decision making in humans.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Biological Psychiatry
Uncontrolled Keywords:Biological Psychiatry
Scope:Discipline-based scholarship (basic research)
Language:English
Date:1 April 2020
Deposited On:16 Jan 2020 12:20
Last Modified:22 Oct 2024 01:40
Publisher:Elsevier
ISSN:0006-3223
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.biopsych.2019.09.002
PubMed ID:31668477
Other Identification Number:merlin-id:19157
Project Information:
  • Funder: SNSF
  • Grant ID: 100014_165884
  • Project Title: The role of dopamine in value-based decision making
  • Funder: SNSF
  • Grant ID: CRSII5_177277
  • Project Title: The Foundations of Successful Financial Decision Making
  • Funder: FP7
  • Grant ID: 219811
  • Project Title: GENS - Genomic Approach to Study the Role of Bacterioplankton in the Sulfur Cycle
  • Funder: FP7
  • Grant ID: 295642
  • Project Title: FEP - Foundations of Economic Preferences
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