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Il-10 producing T and B cells in allergy


Boonpiyathad, Tadech; Satitsuksanoa, Pattraporn; Akdis, Mübeccel; Akdis, Cezmi A (2019). Il-10 producing T and B cells in allergy. Seminars in Immunology, 44:101326.

Abstract

The molecular and cellular mechanisms of allergen tolerance in humans have been intensively studied in the past few decades. The demonstration of epitope-specific T cell tolerance, particularly mediated by the immune suppressor functions of IL-10 led to a major conceptual change in this area more than 20 years ago. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory of T and B cells, the immune suppressive function of secreted factors, such as IL-10, IL-35, IL-1 receptor antagonist and TGF-β, immune suppressive functions of surface molecules such as CTLA-4 and PD-1, the production IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues. In this review, we explain the importance of the role of IL-10 in allergen tolerance.

Abstract

The molecular and cellular mechanisms of allergen tolerance in humans have been intensively studied in the past few decades. The demonstration of epitope-specific T cell tolerance, particularly mediated by the immune suppressor functions of IL-10 led to a major conceptual change in this area more than 20 years ago. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory of T and B cells, the immune suppressive function of secreted factors, such as IL-10, IL-35, IL-1 receptor antagonist and TGF-β, immune suppressive functions of surface molecules such as CTLA-4 and PD-1, the production IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues. In this review, we explain the importance of the role of IL-10 in allergen tolerance.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Immunology, Immunology and Allergy
Language:English
Date:1 August 2019
Deposited On:22 Jan 2020 13:04
Last Modified:22 Jan 2020 13:14
Publisher:Elsevier
ISSN:1044-5323
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.smim.2019.101326
PubMed ID:31711770
Project Information:
  • : FunderSNSF
  • : Grant ID320030_140772
  • : Project TitleRegulation of allergen-specific immune response
  • : FunderFP7
  • : Grant ID261357
  • : Project TitleMEDALL - Mechanisms of the Development of ALLergy
  • : FunderFP7
  • : Grant ID260895
  • : Project TitlePREDICTA - Post-infectious immune reprogramming and its association with persistence and chronicity of respiratory allergic diseases

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