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Deproteinized bovine bone mineral is non-inferior to deproteinized bovine bone mineral with 10% collagen in maintaining the soft tissue contour post-extraction: A randomised trial


Sapata, Vítor M; Llanos, Alexandre H; Cesar Neto, João Batista; Jung, Ronald Ernst; Thoma, Daniel Stefan; Hämmerle, Christoph H F; Pannuti, Claudio M; Romito, Giuseppe A (2020). Deproteinized bovine bone mineral is non-inferior to deproteinized bovine bone mineral with 10% collagen in maintaining the soft tissue contour post-extraction: A randomised trial. Clinical Oral Implants Research, 31(3):294-301.

Abstract

OBJECTIVES
To test the non-inferiority of demineralized bovine bone mineral (DBBM) compared to demineralized bovine bone mineral with 10% collagen (DBBM-C) for the maintenance of the soft tissue contour after tooth extraction in the esthetic zone.
MATERIAL AND METHODS
Sixty-five patients randomly received ridge preservation at a single site in the anterior maxilla with DBBM or DBBM-C. Both, DBBM and DBBM-C were covered with a collagen matrix. Profilometric analyses were performed at baseline (BL), immediately after treatment (PO) and at 4 months (FU; day of implant placement). The main outcome was the horizontal mean change (HC) at the buccal aspect. The measurements also included changes of the estimated soft tissue thickness (eTT) at 1mm, 3mm and 5mm below the buccal gingival margin. Descriptive analysis was performed and differences between groups were analyzed using independent samples t-test. The non-inferiority test was performed for HC.
RESULTS
At 4 months, the horizontal mean change (HC) was -1.43mm (±0.53mm) (DBBM-C) and -1.32mm (±0.53mm) (DBBM). Change of the estimated soft tissue thickness (eTT) between baseline (BL) and four months of follow-up (FU) at 1mm, 3mm and 5mm amounted to -4.58mm (±2.02mm), -2.40mm (±0.97mm) and -1.37mm (±0.78mm) for DBBM-C and to -4.12mm (±1.80mm), -2.09mm (±0.91mm) and -1.23mm (±0.72mm) for DBBM. The differences between the groups were not statistically significantly for any of the outcome measures (p > .05).
CONCLUSIONS
DBBM is non-inferior to DBBM-C for the maintenance of the soft tissue contour 4 months after tooth extraction.

Abstract

OBJECTIVES
To test the non-inferiority of demineralized bovine bone mineral (DBBM) compared to demineralized bovine bone mineral with 10% collagen (DBBM-C) for the maintenance of the soft tissue contour after tooth extraction in the esthetic zone.
MATERIAL AND METHODS
Sixty-five patients randomly received ridge preservation at a single site in the anterior maxilla with DBBM or DBBM-C. Both, DBBM and DBBM-C were covered with a collagen matrix. Profilometric analyses were performed at baseline (BL), immediately after treatment (PO) and at 4 months (FU; day of implant placement). The main outcome was the horizontal mean change (HC) at the buccal aspect. The measurements also included changes of the estimated soft tissue thickness (eTT) at 1mm, 3mm and 5mm below the buccal gingival margin. Descriptive analysis was performed and differences between groups were analyzed using independent samples t-test. The non-inferiority test was performed for HC.
RESULTS
At 4 months, the horizontal mean change (HC) was -1.43mm (±0.53mm) (DBBM-C) and -1.32mm (±0.53mm) (DBBM). Change of the estimated soft tissue thickness (eTT) between baseline (BL) and four months of follow-up (FU) at 1mm, 3mm and 5mm amounted to -4.58mm (±2.02mm), -2.40mm (±0.97mm) and -1.37mm (±0.78mm) for DBBM-C and to -4.12mm (±1.80mm), -2.09mm (±0.91mm) and -1.23mm (±0.72mm) for DBBM. The differences between the groups were not statistically significantly for any of the outcome measures (p > .05).
CONCLUSIONS
DBBM is non-inferior to DBBM-C for the maintenance of the soft tissue contour 4 months after tooth extraction.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic of Reconstructive Dentistry
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oral Surgery
Language:English
Date:March 2020
Deposited On:13 Jan 2020 15:05
Last Modified:30 Dec 2020 01:00
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0905-7161
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/clr.13570
PubMed ID:31886909

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