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Chronic virus infection compromises memory bystander T cell function in an IL-6/STAT1-dependent manner


Barnstorf, Isabel; Borsa, Mariana; Baumann, Nicolas; Pallmer, Katharina; Yermanos, Alexander; Joller, Nicole; Spörri, Roman; Welten, Suzanne P M; Kräutler, Nike J; Oxenius, Annette (2019). Chronic virus infection compromises memory bystander T cell function in an IL-6/STAT1-dependent manner. Journal of Experimental Medicine, 216(3):571-586.

Abstract

Barnstorf et al. demonstrate that chronic viral infections numerically reduce memory non–virus-specific (bystander) cytotoxic T lymphocytes and alter their phenotype and function. Phenotypic changes are induced by the inflammatory cytokine IL-6, and functional impairment is not cell-intrinsic but inferred by the chronically infected host.

Abstract

Barnstorf et al. demonstrate that chronic viral infections numerically reduce memory non–virus-specific (bystander) cytotoxic T lymphocytes and alter their phenotype and function. Phenotypic changes are induced by the inflammatory cytokine IL-6, and functional impairment is not cell-intrinsic but inferred by the chronically infected host.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Immunology and Allergy
Life Sciences > Immunology
Uncontrolled Keywords:Immunology, Immunology and Allergy
Language:English
Date:4 March 2019
Deposited On:29 Jan 2020 13:58
Last Modified:29 Jul 2020 13:04
Publisher:Rockefeller University Press
ISSN:0022-1007
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1084/jem.20181589
PubMed ID:30745322

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