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Role of Co-stimulatory Molecules in T Helper Cell Differentiation


Schorer, Michelle; Kuchroo, Vijay K; Joller, Nicole (2019). Role of Co-stimulatory Molecules in T Helper Cell Differentiation. In: Azuma, Miyuki; Yagita, Hideo. Role of Co-stimulatory Molecules in T Helper Cell Differentiation. Singapore: Springer, 153-177.

Abstract

CD4+ T cells play a central role in orchestrating the immune response to a variety of pathogens but also regulate autoimmune responses, asthma, allergic responses, as well as tumor immunity. To cover this broad spectrum of responses, naïve CD4+ T cells differentiate into one of several lineages of T helper cells, including Th1, Th2, Th17, and TFH, as defined by their cytokine pattern and function. The fate decision of T helper cell differentiation integrates signals delivered through the T cell receptor, cytokine receptors, and the pattern of co-stimulatory signals received. In this review, we summarize the contribution of co-stimulatory and co-inhibitory receptors to the differentiation and maintenance of T helper cell responses.

Abstract

CD4+ T cells play a central role in orchestrating the immune response to a variety of pathogens but also regulate autoimmune responses, asthma, allergic responses, as well as tumor immunity. To cover this broad spectrum of responses, naïve CD4+ T cells differentiate into one of several lineages of T helper cells, including Th1, Th2, Th17, and TFH, as defined by their cytokine pattern and function. The fate decision of T helper cell differentiation integrates signals delivered through the T cell receptor, cytokine receptors, and the pattern of co-stimulatory signals received. In this review, we summarize the contribution of co-stimulatory and co-inhibitory receptors to the differentiation and maintenance of T helper cell responses.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > General Biochemistry, Genetics and Molecular Biology
Language:English
Date:1 January 2019
Deposited On:16 Jan 2020 11:46
Last Modified:22 Apr 2020 22:27
Publisher:Springer
ISBN:978-981-32-9716-6
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-981-32-9717-3_6
PubMed ID:31758534

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