Header

UZH-Logo

Maintenance Infos

Hypoxia-Regulated MicroRNAs in the Retina


Barben, Maya; Bordonhos, Ana; Samardzija, Marijana; Grimm, Christian (2019). Hypoxia-Regulated MicroRNAs in the Retina. Advances in Experimental Medicine and Biology, 1185:413-417.

Abstract

The retina is one of the tissues with the highest metabolic activity in the body, and the energy-demanding photoreceptors require appropriate oxygen levels for photo- and neurotransduction. Accumulating evidence suggests that age-related changes in the retina may reduce oxygen supply to the photoreceptors and trigger a chronic hypoxic response. A detailed understanding of the molecular response to hypoxia is crucial, as hindered oxygen delivery may contribute to the development and progression of retinal pathologies such as age-related macular degeneration (AMD). Important factors in the cellular response to hypoxia are microRNAs (miRNAs), which are small, noncoding RNAs that posttranscriptionally regulate gene expression by binding to mRNA transcripts. Here, we discuss the potential role of hypoxia-regulated miRNAs in connection to retinal pathologies.

Abstract

The retina is one of the tissues with the highest metabolic activity in the body, and the energy-demanding photoreceptors require appropriate oxygen levels for photo- and neurotransduction. Accumulating evidence suggests that age-related changes in the retina may reduce oxygen supply to the photoreceptors and trigger a chronic hypoxic response. A detailed understanding of the molecular response to hypoxia is crucial, as hindered oxygen delivery may contribute to the development and progression of retinal pathologies such as age-related macular degeneration (AMD). Important factors in the cellular response to hypoxia are microRNAs (miRNAs), which are small, noncoding RNAs that posttranscriptionally regulate gene expression by binding to mRNA transcripts. Here, we discuss the potential role of hypoxia-regulated miRNAs in connection to retinal pathologies.

Statistics

Citations

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2019
Deposited On:17 Jan 2020 13:25
Last Modified:17 Jan 2020 13:25
Publisher:Springer
ISSN:0065-2598
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-3-030-27378-1_68
PubMed ID:31884647

Download

Full text not available from this repository.
View at publisher

Get full-text in a library