Header

UZH-Logo

Maintenance Infos

Rodent models of obesity


Doulberis, Michael; Papaefthymiou, Apostolis; Polyzos, Stergios A; Katsinelos, Panagiotis; Grigoriadis, Nikolaos; Srivastava, David S; Kountouras, Jannis (2019). Rodent models of obesity. Minerva Endocrinologica:Epub ahead of print.

Abstract

Obese or overweight people exceed one-third of the global population and obesity along with diabetes mellitus consist basic components of metabolic syndrome, both of which are known cardio-cerebrovascular risk factors with detrimental consequences. These data signify the pandemic character of obesity and the necessity for effective treatments. Substantial advances have been accomplished in preclinical research of obesity by using animal models, which mimic the human disease. In particular, rodent models have been widely used for many decades with success for the elucidation of the pathophysiology of obesity, since they share physiological and genetic components with humans and appear advantageous in their husbandry. The most representative rodents include the laboratory mouse and rat. Within this review, we attempted to consolidate the most widely used mice and rat models of obesity and highlight their strengths as well as weaknesses in a critical way. Our aim was to bridge the gap between laboratory facilities and patient's bed and help the researcher find the appropriate animal model for his/her obesity research. This tactful selection of the appropriate model of obesity may offer more translational the derived results.. In this regard, we included, the main diet induced models, the chemical/mechanical ones as well as a selection of monogenic or polygenic models.

Abstract

Obese or overweight people exceed one-third of the global population and obesity along with diabetes mellitus consist basic components of metabolic syndrome, both of which are known cardio-cerebrovascular risk factors with detrimental consequences. These data signify the pandemic character of obesity and the necessity for effective treatments. Substantial advances have been accomplished in preclinical research of obesity by using animal models, which mimic the human disease. In particular, rodent models have been widely used for many decades with success for the elucidation of the pathophysiology of obesity, since they share physiological and genetic components with humans and appear advantageous in their husbandry. The most representative rodents include the laboratory mouse and rat. Within this review, we attempted to consolidate the most widely used mice and rat models of obesity and highlight their strengths as well as weaknesses in a critical way. Our aim was to bridge the gap between laboratory facilities and patient's bed and help the researcher find the appropriate animal model for his/her obesity research. This tactful selection of the appropriate model of obesity may offer more translational the derived results.. In this regard, we included, the main diet induced models, the chemical/mechanical ones as well as a selection of monogenic or polygenic models.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

1 download since deposited on 03 Feb 2020
1 download since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:13 November 2019
Deposited On:03 Feb 2020 15:38
Last Modified:04 Feb 2020 13:44
Publisher:Edizioni Minerva Medica
ISSN:0391-1977
OA Status:Closed
Publisher DOI:https://doi.org/10.23736/S0391-1977.19.03058-X
PubMed ID:31738033

Download

Closed Access: Download allowed only for UZH members

Content: Accepted Version
Filetype: PDF - Registered users only until 13 November 2020
Size: 302kB
View at publisher
Embargo till: 2020-11-13