Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Personode: A Toolbox for ICA Map Classification and Individualized ROI Definition

Pamplona, Gustavo S P; Vieira, Bruno H; Scharnowski, Frank; Salmon, Carlos E G (2020). Personode: A Toolbox for ICA Map Classification and Individualized ROI Definition. Neuroinformatics, 18(3):339-349.

Abstract

Canonical resting state networks (RSNs) can be obtained through independent component analysis (ICA). RSNs are reproducible across subjects but also present inter-individual differences, which can be used to individualize regions-of-interest (ROI) definition, thus making fMRI analyses more accurate. Unfortunately, no automatic tool for defining subject-specific ROIs exists, making the classification of ICAs as representatives of RSN time-consuming and largely dependent on visual inspection. Here, we present Personode, a user-friendly and open source MATLAB-based toolbox that semi-automatically performs the classification of RSN and allows for defining subject- and group-specific ROIs. To validate the applicability of our new approach and to assess potential improvements compared to previous approaches, we applied Personode to both task-related activation and resting-state data. Our analyses show that for task-related activation analyses, subject-specific spherical ROIs defined with Personode produced higher activity contrasts compared to ROIs derived from single-study and meta-analytic coordinates. We also show that subject-specific irregular ROIs defined with Personode improved ROI-to-ROI functional connectivity analyses.Hence, Personode might be a useful toolbox for ICA map classification into RSNs and group- as well as subject-specific ROI definitions, leading to improved analyses of task-related activation and functional connectivity.

Keywords: Functional connectivity; ICA map classification; Independent component analysis; ROI individualization; Resting-state networks; Toolbox.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
04 Faculty of Medicine > Zurich Center for Integrative Human Physiology (ZIHP)
04 Faculty of Medicine > Neuroscience Center Zurich
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Physical Sciences > Software
Life Sciences > General Neuroscience
Physical Sciences > Information Systems
Language:English
Date:2020
Deposited On:31 Mar 2022 10:47
Last Modified:22 Oct 2024 01:41
Publisher:Springer
ISSN:1539-2791
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s12021-019-09449-4
PubMed ID:31900722
Full text not available from this repository.

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
7 citations in Web of Science®
6 citations in Scopus®
Google Scholar™

Altmetrics

Authors, Affiliations, Collaborations

Similar Publications