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Track event theory: a cell survival and rbe model consistent with nanodosimetry


Schneider, Uwe; Vasi, Fabiano; Schmidli, Kevin; Besserer, Jürgen (2019). Track event theory: a cell survival and rbe model consistent with nanodosimetry. Radiation Protection Dosimetry, 183(1-2):17-21.

Abstract

A simple model for cell survival which is valid also at high dose has been developed. The model parameters can be traced back to measurable quantities from nanodosimetry. It is assumed that a cell is killed by an event which is defined by two or more double strand breaks in differently sized lethal interaction volumes (LIVs). Two different mechanisms can produce events, one-track events by one-particle track and two-track events by two. One- and two-track events are statistically independent. From the stochastic nature of cell killing which is described by the Poisson distribution, the cell survival probability was derived. The ratio of the number of one- and two-track events can be directly expressed in terms of nanodosimetry by the probability F2 that at least two ionizations are produced in a basic interaction volume (5–10 base pairs). From the model, relative biological effectiveness (RBE) can be derived which depends only on F2 and the size of the LIV. The expression for RBE fits experimental data with satisfying quality.

Abstract

A simple model for cell survival which is valid also at high dose has been developed. The model parameters can be traced back to measurable quantities from nanodosimetry. It is assumed that a cell is killed by an event which is defined by two or more double strand breaks in differently sized lethal interaction volumes (LIVs). Two different mechanisms can produce events, one-track events by one-particle track and two-track events by two. One- and two-track events are statistically independent. From the stochastic nature of cell killing which is described by the Poisson distribution, the cell survival probability was derived. The ratio of the number of one- and two-track events can be directly expressed in terms of nanodosimetry by the probability F2 that at least two ionizations are produced in a basic interaction volume (5–10 base pairs). From the model, relative biological effectiveness (RBE) can be derived which depends only on F2 and the size of the LIV. The expression for RBE fits experimental data with satisfying quality.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Physics Institute
Dewey Decimal Classification:530 Physics
Scopus Subject Areas:Health Sciences > Radiological and Ultrasound Technology
Physical Sciences > Radiation
Health Sciences > Radiology, Nuclear Medicine and Imaging
Health Sciences > Public Health, Environmental and Occupational Health
Uncontrolled Keywords:Radiological and Ultrasound Technology, Public Health, Environmental and Occupational Health, Radiation, Radiology Nuclear Medicine and imaging, General Medicine
Language:English
Date:1 May 2019
Deposited On:04 Feb 2020 15:38
Last Modified:29 Jul 2020 13:20
Publisher:Oxford University Press
ISSN:0144-8420
OA Status:Closed
Publisher DOI:https://doi.org/10.1093/rpd/ncy236

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