Header

UZH-Logo

Maintenance Infos

Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks


Zheng, Jia; Payne, Joshua L; Wagner, Andreas (2019). Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks. Science, 365(6451):347-353.

Abstract

Cryptic genetic variation can facilitate adaptation in evolving populations. To elucidate the underlying genetic mechanisms, we used directed evolution in <jats:italic>Escherichia coli</jats:italic> to accumulate variation in populations of yellow fluorescent proteins and then evolved these proteins toward the new phenotype of green fluorescence. Populations with cryptic variation evolved adaptive genotypes with greater diversity and higher fitness than populations without cryptic variation, which converged on similar genotypes. Populations with cryptic variation accumulated neutral or deleterious mutations that break the constraints on the order in which adaptive mutations arise. In doing so, cryptic variation opens paths to adaptive genotypes, creates historical contingency, and reduces the predictability of evolution by allowing different replicate populations to climb different adaptive peaks and explore otherwise-inaccessible regions of an adaptive landscape.

Abstract

Cryptic genetic variation can facilitate adaptation in evolving populations. To elucidate the underlying genetic mechanisms, we used directed evolution in <jats:italic>Escherichia coli</jats:italic> to accumulate variation in populations of yellow fluorescent proteins and then evolved these proteins toward the new phenotype of green fluorescence. Populations with cryptic variation evolved adaptive genotypes with greater diversity and higher fitness than populations without cryptic variation, which converged on similar genotypes. Populations with cryptic variation accumulated neutral or deleterious mutations that break the constraints on the order in which adaptive mutations arise. In doing so, cryptic variation opens paths to adaptive genotypes, creates historical contingency, and reduces the predictability of evolution by allowing different replicate populations to climb different adaptive peaks and explore otherwise-inaccessible regions of an adaptive landscape.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

8 downloads since deposited on 07 Feb 2020
8 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Uncontrolled Keywords:Multidisciplinary
Language:English
Date:26 July 2019
Deposited On:07 Feb 2020 09:02
Last Modified:12 Feb 2020 13:36
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
Additional Information:This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science https://doi.org/10.1126/science.aax1837
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1126/science.aax1837
Project Information:
  • : FunderSNSF
  • : Grant IDPP00P3_170604
  • : Project TitleRegulatory logic and the evolution of promoter complexity
  • : FunderSNSF
  • : Grant ID31003A_172887
  • : Project TitleRobustness and weakened selection in the adaptive evolution of fluorescent proteins

Download

Green Open Access

Download PDF  'Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks'.
Preview
Content: Accepted Version
Filetype: PDF
Size: 29MB
View at publisher