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A potential role of lymphangiogenesis for peripheral nerve injury and regeneration


Frueh, Florian S; Gousopoulos, Epameinondas; Power, Dominic M; Ampofo, Emmanuel; Giovanoli, Pietro; Calcagni, Maurizio; Laschke, Matthias W (2020). A potential role of lymphangiogenesis for peripheral nerve injury and regeneration. Medical Hypotheses, 135:109470.

Abstract

Traumatic peripheral nerve injuries are common and socioeconomically highly relevant. Despite significant microsurgical advances, the results of surgical reconstruction are still far from optimal and the rate of life-long complications, such as impaired motor and sensory function or neuropathic pain, is high. Moreover, the regeneration of peripheral nerves is a complex and fragile process that is not yet completely understood. Hence, there is an urgent need to further elucidate the underlying biological mechanisms. Herein, we propose that the neural lymphatic vasculature and lymphangiogenesis play an essential role in both peripheral nerve injury and regeneration and discuss hypothetical mechanisms implementing the current literature. Finally, specific research approaches to test our hypothesis are introduced.

Abstract

Traumatic peripheral nerve injuries are common and socioeconomically highly relevant. Despite significant microsurgical advances, the results of surgical reconstruction are still far from optimal and the rate of life-long complications, such as impaired motor and sensory function or neuropathic pain, is high. Moreover, the regeneration of peripheral nerves is a complex and fragile process that is not yet completely understood. Hence, there is an urgent need to further elucidate the underlying biological mechanisms. Herein, we propose that the neural lymphatic vasculature and lymphangiogenesis play an essential role in both peripheral nerve injury and regeneration and discuss hypothetical mechanisms implementing the current literature. Finally, specific research approaches to test our hypothesis are introduced.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Reconstructive Surgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > General Medicine
Language:English
Date:2020
Deposited On:03 Feb 2020 16:04
Last Modified:29 Jul 2020 13:35
Publisher:Churchill Livingstone
ISSN:0306-9877
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.mehy.2019.109470
PubMed ID:31734377

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