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Automatic Determination of Left- and Right-Hand Bone Age in the First Zurich Longitudinal Study


Martin, David D; Neuhof, Julia; Jenni, Oskar G; Ranke, Michael B; Thodberg, Hans Henrik (2010). Automatic Determination of Left- and Right-Hand Bone Age in the First Zurich Longitudinal Study. Hormone Research in Paediatrics, 74(1):50-55.

Abstract

BACKGROUND/AIMS:

A more advanced bone age (BA) has been reported for the left hand relative to the right hand, while another study has found no such effect. The aim was to study the average difference of automated BoneXpert BA determination (left- vs. right-hand) for normal children, examine the precision of automatic BA and provide a BA reference for normal Caucasian children.

METHODS:

Radiographs of both hands (age range: 2-20 years) were digitised and analysed automatically to determine Greulich-Pyle BA, producing analysis results for 3,374 left-hand and 2,752 right-hand images.

RESULTS:

Comparison of left- and right-hand BA showed no average difference (<0.07 years, 95% confidence). The SD of the differences between left and right sides was 0.25 years for boys as well as girls, implying the precision of automated Greulich-Pyle BA determination was 0.18 years or better. Greulich-Pyle BA for boys and girls were on average 0.10 and 0.21 years below the chronological age.

CONCLUSION:

The left and right hand give the same BA on average and the SD between the sides is 0.25 years, indicating an excellent precision of the automated method.

Abstract

BACKGROUND/AIMS:

A more advanced bone age (BA) has been reported for the left hand relative to the right hand, while another study has found no such effect. The aim was to study the average difference of automated BoneXpert BA determination (left- vs. right-hand) for normal children, examine the precision of automatic BA and provide a BA reference for normal Caucasian children.

METHODS:

Radiographs of both hands (age range: 2-20 years) were digitised and analysed automatically to determine Greulich-Pyle BA, producing analysis results for 3,374 left-hand and 2,752 right-hand images.

RESULTS:

Comparison of left- and right-hand BA showed no average difference (<0.07 years, 95% confidence). The SD of the differences between left and right sides was 0.25 years for boys as well as girls, implying the precision of automated Greulich-Pyle BA determination was 0.18 years or better. Greulich-Pyle BA for boys and girls were on average 0.10 and 0.21 years below the chronological age.

CONCLUSION:

The left and right hand give the same BA on average and the SD between the sides is 0.25 years, indicating an excellent precision of the automated method.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pediatrics, Perinatology and Child Health
Health Sciences > Endocrinology, Diabetes and Metabolism
Life Sciences > Endocrinology
Language:English
Date:1 January 2010
Deposited On:19 Feb 2020 16:56
Last Modified:31 Jul 2020 03:46
Publisher:Karger
ISSN:1663-2818
OA Status:Green
Publisher DOI:https://doi.org/10.1159/000313369
PubMed ID:20395658

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