Header

UZH-Logo

Maintenance Infos

Spindle Activity in Children During Cardiac Surgery and Hypothermic Cardiopulmonary Bypass


Schmitt, Bernhard; Jenni, Oskar G; Bauersfeld, Urs; Schüpbach, Rolf; Schmid, Edith R (2002). Spindle Activity in Children During Cardiac Surgery and Hypothermic Cardiopulmonary Bypass. Journal of Clinical Neurophysiology, 19(6):547-552.

Abstract

Hypothermia has marked effects on the electrical activity of the brain, which has been shown in animals as well as in humans. The aim of this study was to investigate EEG spindle activity in children during cardiac surgery and hypothermic cardiopulmonary bypass. The authors obtained intraoperative 21-channel EEG recordings in 36 children (mean age, 22 months; range, 6 days to 69 months) with congenital heart disease. Bipolar EEG derivations were analyzed visually for rhythmic spindle activity based on morphology, frequency, duration, and amplitude. Linear regression analysis for duration, frequency, and amplitude versus rectal temperature was performed in each individual. Spindle activity was observed in 17 children (16 children < 12 months of age). Progressive slowing of spindle frequency with decreasing rectal temperature was found (mean decrease, 0.54 +/- 0.31 Hz/ degrees C). Spindle duration increased on average by 0.69 +/- 0.39 second/ degrees C during cooling procedures. Spindle amplitude did not show any correlation to changes in rectal temperature. The current study demonstrates spindle activity during hypothermic cardiopulmonary bypass with temperature-dependent spindle modifications of frequency and duration. Although the temperature-dependent changes in this study confirm temperature coefficients of other EEG studies, the reasons for the clear age relationship and the "nature" of these spindles remain unknown.

Abstract

Hypothermia has marked effects on the electrical activity of the brain, which has been shown in animals as well as in humans. The aim of this study was to investigate EEG spindle activity in children during cardiac surgery and hypothermic cardiopulmonary bypass. The authors obtained intraoperative 21-channel EEG recordings in 36 children (mean age, 22 months; range, 6 days to 69 months) with congenital heart disease. Bipolar EEG derivations were analyzed visually for rhythmic spindle activity based on morphology, frequency, duration, and amplitude. Linear regression analysis for duration, frequency, and amplitude versus rectal temperature was performed in each individual. Spindle activity was observed in 17 children (16 children < 12 months of age). Progressive slowing of spindle frequency with decreasing rectal temperature was found (mean decrease, 0.54 +/- 0.31 Hz/ degrees C). Spindle duration increased on average by 0.69 +/- 0.39 second/ degrees C during cooling procedures. Spindle amplitude did not show any correlation to changes in rectal temperature. The current study demonstrates spindle activity during hypothermic cardiopulmonary bypass with temperature-dependent spindle modifications of frequency and duration. Although the temperature-dependent changes in this study confirm temperature coefficients of other EEG studies, the reasons for the clear age relationship and the "nature" of these spindles remain unknown.

Statistics

Citations

Dimensions.ai Metrics
5 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

22 downloads since deposited on 20 Feb 2020
13 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Life Sciences > Neurology
Health Sciences > Neurology (clinical)
Health Sciences > Physiology (medical)
Uncontrolled Keywords:Physiology (medical), Physiology, Neurology, Clinical Neurology
Language:English
Date:1 December 2002
Deposited On:20 Feb 2020 08:33
Last Modified:31 Jul 2020 03:46
Publisher:Lippincott Williams & Wilkins
ISSN:0736-0258
OA Status:Green
Publisher DOI:https://doi.org/10.1097/00004691-200212000-00008
PubMed ID:12488786

Download

Green Open Access

Download PDF  'Spindle Activity in Children During Cardiac Surgery and Hypothermic Cardiopulmonary Bypass'.
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 366kB
View at publisher