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Outcomes and Long-term Follow-up of Patients with Cystine Stones: a Systematic Review


Moore, Sacha L; Cook, Paul; de Coninck, Vincent; Keller, Etienne Xavier; Traxer, Olivier; Dragos, Laurian; Shergill, Iqbal S; Somani, Bhaskar K (2019). Outcomes and Long-term Follow-up of Patients with Cystine Stones: a Systematic Review. Current Urology Reports, 20(6):27.

Abstract

PURPOSE OF REVIEW

Cystine stone patients can be difficult to manage with frequent recurrences. We performed a systematic review with a view to assessing interventions, compliance and their long-term outcomes.

RECENT FINDINGS

Ten retrospective observational studies (253 patients) assessed the outcomes and long-term follow-up of cystine stone patients. The mean length of follow-up was 9.6 years (range 3.5-21.8 years). The overall mean number of surgical procedures/patient was 5.7 (range 2-9.8/patient) with the overall mean number of surgical procedures/patient/year at 0.59 (range 0.22-1.32/patient/year). While open surgery has decreased over the last decade and PCNL has been stable, there seems to be a rise of RIRS during this period. Patients with cystine stones need periodic interventions for stone recurrences despite medical management, with limited data showing the impact on renal function. While the management is individualised, wide variability exists with often poor and incomplete patient data.

Abstract

PURPOSE OF REVIEW

Cystine stone patients can be difficult to manage with frequent recurrences. We performed a systematic review with a view to assessing interventions, compliance and their long-term outcomes.

RECENT FINDINGS

Ten retrospective observational studies (253 patients) assessed the outcomes and long-term follow-up of cystine stone patients. The mean length of follow-up was 9.6 years (range 3.5-21.8 years). The overall mean number of surgical procedures/patient was 5.7 (range 2-9.8/patient) with the overall mean number of surgical procedures/patient/year at 0.59 (range 0.22-1.32/patient/year). While open surgery has decreased over the last decade and PCNL has been stable, there seems to be a rise of RIRS during this period. Patients with cystine stones need periodic interventions for stone recurrences despite medical management, with limited data showing the impact on renal function. While the management is individualised, wide variability exists with often poor and incomplete patient data.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Urology
Language:English
Date:15 April 2019
Deposited On:07 Feb 2020 11:23
Last Modified:29 Jul 2020 13:45
Publisher:Springer
ISSN:1527-2737
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s11934-019-0891-7
PubMed ID:30989375

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