Header

UZH-Logo

Maintenance Infos

Correlates of broadly neutralizing antibody development


Abela, Irene A; Kadelka, Claus; Trkola, Alexandra (2019). Correlates of broadly neutralizing antibody development. Current opinion in HIV and AIDS, 14(4):279-285.

Abstract

PURPOSE OF REVIEW

Broadly neutralizing antibodies (bnAbs) are considered a key component of an effective HIV-1 vaccine, but despite intensive efforts, induction of bnAbs by vaccination has thus far not been possible. Potent bnAb activity is rare in natural infection and a deeper understanding of factors that promote or limit bnAb evolution is critical to guide bnAb vaccine development. This review reflects on recent key discoveries on correlates of bnAb development and discusses what further insights are needed to move forward.

RECENT FINDINGS

An increasing number of parameters have been implicated to influence bnAb development in natural infection. Most recent findings highlight a range of immune factors linked with bnAb evolution. Novel approaches have brought exciting progress in defining signatures of the viral envelope associated with bnAb activity.

SUMMARY

Focused efforts of recent years have unraveled a multiply layered process of HIV-1 bnAb development. As it is understood today, bnAb evolution can be triggered and influenced by a range of factors and several different pathways may exist how bnAb induction and maturation can occur. To capitalize on the gained knowledge, future research needs to validate factors to identify independent drivers of bnAb induction to advance vaccine design.

Abstract

PURPOSE OF REVIEW

Broadly neutralizing antibodies (bnAbs) are considered a key component of an effective HIV-1 vaccine, but despite intensive efforts, induction of bnAbs by vaccination has thus far not been possible. Potent bnAb activity is rare in natural infection and a deeper understanding of factors that promote or limit bnAb evolution is critical to guide bnAb vaccine development. This review reflects on recent key discoveries on correlates of bnAb development and discusses what further insights are needed to move forward.

RECENT FINDINGS

An increasing number of parameters have been implicated to influence bnAb development in natural infection. Most recent findings highlight a range of immune factors linked with bnAb evolution. Novel approaches have brought exciting progress in defining signatures of the viral envelope associated with bnAb activity.

SUMMARY

Focused efforts of recent years have unraveled a multiply layered process of HIV-1 bnAb development. As it is understood today, bnAb evolution can be triggered and influenced by a range of factors and several different pathways may exist how bnAb induction and maturation can occur. To capitalize on the gained knowledge, future research needs to validate factors to identify independent drivers of bnAb induction to advance vaccine design.

Statistics

Citations

Altmetrics

Downloads

0 downloads since deposited on 07 Feb 2020
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Immunology
Health Sciences > Hematology
Health Sciences > Oncology
Health Sciences > Oncology (nursing)
Health Sciences > Infectious Diseases
Life Sciences > Virology
Language:English
Date:July 2019
Deposited On:07 Feb 2020 10:31
Last Modified:01 Aug 2020 00:02
Publisher:Lippincott Williams & Wilkins
ISSN:1746-630X
OA Status:Green
Publisher DOI:https://doi.org/10.1097/COH.0000000000000552
PubMed ID:31107283

Download

Green Open Access

Download PDF  'Correlates of broadly neutralizing antibody development'.
Preview
Content: Published Version
Filetype: PDF
Size: 422kB
View at publisher