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Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes)


Triplett, James D; Buzzard, Katherine A; Lubomski, Michal; Riminton, D Sean; Barnett, Michael H; Welgampola, Miriam S; Halmagyi, G Michael; Nguyen, MaiAnh; Landau, Klara; Lee, Andrew G; Plant, Gordon T; Fraser, Clare L; Reddel, Stephen W; Hardy, Todd A (2019). Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes). Journal of Neurology, Neurosurgery, and Psychiatry, 90(8):882-894.

Abstract

The triad of central nervous system symptoms, visual disturbance and hearing impairment is an oft-encountered clinical scenario. A number of immune-mediated diseases should be considered among the differential diagnoses including: Susac syndrome, Cogan syndrome or Vogt-Koyanagi-Harada disease; demyelinating conditions such as multiple sclerosis or neuromyelitis optica spectrum disorder; systemic diseases such as systemic lupus erythematosus, Sjögren syndrome or Behcet disease and granulomatous diseases such as sarcoidosis. In this article, we coin the term 'BEE syndromes' to draw attention to the various immune-mediated diseases that affect the brain, eye and ear. We present common disease manifestations and identify key clinical and investigation features.

Abstract

The triad of central nervous system symptoms, visual disturbance and hearing impairment is an oft-encountered clinical scenario. A number of immune-mediated diseases should be considered among the differential diagnoses including: Susac syndrome, Cogan syndrome or Vogt-Koyanagi-Harada disease; demyelinating conditions such as multiple sclerosis or neuromyelitis optica spectrum disorder; systemic diseases such as systemic lupus erythematosus, Sjögren syndrome or Behcet disease and granulomatous diseases such as sarcoidosis. In this article, we coin the term 'BEE syndromes' to draw attention to the various immune-mediated diseases that affect the brain, eye and ear. We present common disease manifestations and identify key clinical and investigation features.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:August 2019
Deposited On:07 Feb 2020 15:56
Last Modified:07 Feb 2020 15:56
Publisher:BMJ Publishing Group
ISSN:0022-3050
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1136/jnnp-2018-319002
PubMed ID:30852493

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