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Investigating the Structure and Dynamics of Apo‐Photosystem II


Han, Ruocheng; Rempfer, Katharina; Zhang, Miao; Dobbek, Holger; Zouni, Athina; Dau, Holger; Luber, Sandra (2019). Investigating the Structure and Dynamics of Apo‐Photosystem II. ChemCatChem, 11(16):4072-4080.

Abstract

Photosynthetic water oxidation is a model for future technologies employing solar energy to split water into hydrogen and oxygen. Natural water oxidation is carried out by a special manganese catalyst, the water-oxidizing complex (WOC), located in photosystem II (PSII) of cyanobacteria, algae, and plants. Hence, there is great interest in the molecular structure as well as structural changes during catalytic activity and assembly/disassembly of the WOC. In particular, the light-driven assembly during photosystem II repair under physiological conditions is poorly understood, and structural information about manganese depleted PSII (apo-PSII) is required as a starting point for improving this understanding. Recently Zhang et al. (eLife 2017;6:e26933) showed that the cavity harboring the WOC in PSII remains largely intact upon manganesedepletion and suggested that deprotonation of hydrogen-bonding pairs enables the charge-compensated insertion of the manganese cations without any major change of the cavity structure. By computational methods we have further investigated the structure of apo-PSII and show how it can be stabilized by protons localized at the terminal carboxylate groups inside the remaining cavity. Ab-initio molecular dynamics simulations suggest that not more than two water molecules fill the void left by manganese depletion.

Abstract

Photosynthetic water oxidation is a model for future technologies employing solar energy to split water into hydrogen and oxygen. Natural water oxidation is carried out by a special manganese catalyst, the water-oxidizing complex (WOC), located in photosystem II (PSII) of cyanobacteria, algae, and plants. Hence, there is great interest in the molecular structure as well as structural changes during catalytic activity and assembly/disassembly of the WOC. In particular, the light-driven assembly during photosystem II repair under physiological conditions is poorly understood, and structural information about manganese depleted PSII (apo-PSII) is required as a starting point for improving this understanding. Recently Zhang et al. (eLife 2017;6:e26933) showed that the cavity harboring the WOC in PSII remains largely intact upon manganesedepletion and suggested that deprotonation of hydrogen-bonding pairs enables the charge-compensated insertion of the manganese cations without any major change of the cavity structure. By computational methods we have further investigated the structure of apo-PSII and show how it can be stabilized by protons localized at the terminal carboxylate groups inside the remaining cavity. Ab-initio molecular dynamics simulations suggest that not more than two water molecules fill the void left by manganese depletion.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:21 August 2019
Deposited On:07 Feb 2020 13:46
Last Modified:10 Feb 2020 09:27
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1867-3880
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/cctc.201900351
Project Information:
  • : FunderSNSF
  • : Grant IDPP00P2_170667
  • : Project TitleIn Silico Investigation and Design of Bio-inspired Catalysts for Water Splitting

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Embargo till: 2020-08-21