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Progress of malignant mesothelioma research in basic science: a review of the 14th international conference of the international mesothelioma interest group (iMig2018)


Wu, Licun; Dell'Anno, Irene; Lapidot, Moshe; Sekido, Yoshitaka; Chan, Mei-Lin; Kohno, Mikihiro; Serre-Beinier, Veronique; Felley-Bosco, Emanuela; de Perrot, Marc (2019). Progress of malignant mesothelioma research in basic science: a review of the 14th international conference of the international mesothelioma interest group (iMig2018). Lung Cancer, 127:138-145.

Abstract

Here we summarize the most recent update of mesothelioma research in basic science presented at the 14$^{th}$ iMig2018 international conference. The symposium of basic science track mainly focused on the drivers of mesothelioma initiation and progression, molecular pathogenesis, and perspectives on potential therapeutic approaches. This review covers several promising fields including strategies efficiently inhibiting YAP/TAZ functions or their critical downstream targets, heparanase inhibitors, RAN depletion, and MIF/CD74 inhibitors that may be developed as novel therapeutic approaches. In addition, targeting mesothelioma stem cells by depleting M2-polarized macrophages in tumor microenvironment or blocking Tnfsf18 (GITRL)-GITR signalling might be translated into therapeutic modalities in mesothelioma treatment.

Abstract

Here we summarize the most recent update of mesothelioma research in basic science presented at the 14$^{th}$ iMig2018 international conference. The symposium of basic science track mainly focused on the drivers of mesothelioma initiation and progression, molecular pathogenesis, and perspectives on potential therapeutic approaches. This review covers several promising fields including strategies efficiently inhibiting YAP/TAZ functions or their critical downstream targets, heparanase inhibitors, RAN depletion, and MIF/CD74 inhibitors that may be developed as novel therapeutic approaches. In addition, targeting mesothelioma stem cells by depleting M2-polarized macrophages in tumor microenvironment or blocking Tnfsf18 (GITRL)-GITR signalling might be translated into therapeutic modalities in mesothelioma treatment.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Asbestos exposure; International mesothelioma interest group (iMig); Malignant pleural mesothelioma (MPM); Molecular pathogenesis; Therapeutic approach
Language:English
Date:January 2019
Deposited On:10 Feb 2020 15:33
Last Modified:10 Feb 2020 15:33
Publisher:Elsevier
ISSN:0169-5002
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.lungcan.2018.11.034
PubMed ID:30642542

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