Header

UZH-Logo

Maintenance Infos

Microglia in the developing brain: from immunity to behaviour


Schlegelmilch, Timm; Henke, Katrin; Peri, Francesca (2011). Microglia in the developing brain: from immunity to behaviour. Current Opinion in Neurobiology, 21(1):5-10.

Abstract

For decades, microglia, the resident macrophages of the brain, have been recognized mostly for their role in several, if not all, pathologies affecting the brain. However, several studies under physiological conditions demonstrate that microglial function is indispensable also in the healthy brain. Indeed, microglia implement key functions already during development, such as the clearance of the huge amount of neurons that are produced in large excess in the embryo and later die of apoptosis. Beside these classical functions, however, novel roles are emerging that strikingly link microglia with higher order brain functions and show that these cells can ultimately influence behaviour. Therefore a detailed understanding of microglia under physiological conditions may open unprecedented perspectives in the prevention and treatment of neuropsychiatric diseases.

Abstract

For decades, microglia, the resident macrophages of the brain, have been recognized mostly for their role in several, if not all, pathologies affecting the brain. However, several studies under physiological conditions demonstrate that microglial function is indispensable also in the healthy brain. Indeed, microglia implement key functions already during development, such as the clearance of the huge amount of neurons that are produced in large excess in the embryo and later die of apoptosis. Beside these classical functions, however, novel roles are emerging that strikingly link microglia with higher order brain functions and show that these cells can ultimately influence behaviour. Therefore a detailed understanding of microglia under physiological conditions may open unprecedented perspectives in the prevention and treatment of neuropsychiatric diseases.

Statistics

Citations

Dimensions.ai Metrics
66 citations in Web of Science®
75 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > General Neuroscience
Language:English
Date:1 February 2011
Deposited On:19 Feb 2020 16:52
Last Modified:31 Jul 2020 03:47
Publisher:Elsevier
ISSN:0959-4388
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.conb.2010.08.004

Download

Full text not available from this repository.
View at publisher

Get full-text in a library