Header

UZH-Logo

Maintenance Infos

Breaking ranks: how leukocytes react to developmental cues and tissue injury


Peri, Francesca (2010). Breaking ranks: how leukocytes react to developmental cues and tissue injury. Current Opinion in Genetics & Development, 20(4):416-419.

Abstract

Leukocytes are arguably the most motile cells in metazoans. Besides their well-described ability to migrate rapidly toward sites of tissue injury, tissue-specific macrophages migrate already during embryogenesis, when they take up residence in a wide range of organs. The recent identification of molecules responsible for the guidance of leukocytes during development and in response to injury has revealed that these modes of migration are under the control of surprisingly different signaling systems. While the developmental migrations are regulated by hard-wired pre-patterns of secreted proteins, the rapid acute response to injury involves signals like hydrogen peroxide or extracellular nucleotides such as ATP. Ongoing work aims to understand how these distinct signals are integrated in the cell to determine different cellular responses.

Abstract

Leukocytes are arguably the most motile cells in metazoans. Besides their well-described ability to migrate rapidly toward sites of tissue injury, tissue-specific macrophages migrate already during embryogenesis, when they take up residence in a wide range of organs. The recent identification of molecules responsible for the guidance of leukocytes during development and in response to injury has revealed that these modes of migration are under the control of surprisingly different signaling systems. While the developmental migrations are regulated by hard-wired pre-patterns of secreted proteins, the rapid acute response to injury involves signals like hydrogen peroxide or extracellular nucleotides such as ATP. Ongoing work aims to understand how these distinct signals are integrated in the cell to determine different cellular responses.

Statistics

Citations

Dimensions.ai Metrics
5 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Genetics
Life Sciences > Developmental Biology
Language:English
Date:1 August 2010
Deposited On:19 Feb 2020 17:06
Last Modified:31 Jul 2020 03:47
Publisher:Elsevier
ISSN:0959-437X
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.gde.2010.05.002
PubMed ID:20627699

Download

Full text not available from this repository.
View at publisher

Get full-text in a library