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SR-BI as a target of natural products and its significance in cancer


Wang, Dongdong; Huang, Jiansheng; Gui, Ting; Yang, Yaxin; Feng, Tingting; Tzvetkov, Nikolay T; Xu, Tao; Gai, Zhibo; Zhou, Ying; Zhang, Jingjie; Atanasov, Atanas G (2020). SR-BI as a target of natural products and its significance in cancer. Seminars in Cancer Biology:Epub ahead of print.

Abstract

Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi-directional flux of free cholesterol. Recently, SR-BI has also been identified as a potential marker for cancer diagnosis, prognosis, or even a treatment target. Natural products are a promising source for the discovery of new drug leads. Multiple natural products were identified to regulate SR-BI protein expression. There are still a number of challenges in modulating SR-BI expression in cancer and in using natural products for modulation of such protein expression. In this review, our purpose is to discuss the relationship between SR-BI protein and cancer, and the molecular mechanisms regulating SR-BI expression, as well as to provide an overview of natural products that regulate SR-BI expression.

Abstract

Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi-directional flux of free cholesterol. Recently, SR-BI has also been identified as a potential marker for cancer diagnosis, prognosis, or even a treatment target. Natural products are a promising source for the discovery of new drug leads. Multiple natural products were identified to regulate SR-BI protein expression. There are still a number of challenges in modulating SR-BI expression in cancer and in using natural products for modulation of such protein expression. In this review, our purpose is to discuss the relationship between SR-BI protein and cancer, and the molecular mechanisms regulating SR-BI expression, as well as to provide an overview of natural products that regulate SR-BI expression.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Cancer Research
Language:English
Date:1 January 2020
Deposited On:14 Feb 2020 16:14
Last Modified:14 Feb 2020 16:14
Publisher:Elsevier
ISSN:1044-579X
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.semcancer.2019.12.025

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Content: Accepted Version
Language: English
Filetype: PDF - Registered users only until 12 January 2021
Size: 794kB
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Embargo till: 2021-01-12