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First clinical case of in vivo acquisition of DHA-1 plasmid-mediated AmpC in a salmonella enterica subsp. enterica isolate


Clément, Mathieu; Keller, Peter M; Bernasconi, Odette J; Stirnimann, Guido; Frey, Pascal M; Bloemberg, Guido V; Sendi, Parham; Endimiani, Andrea (2019). First clinical case of in vivo acquisition of DHA-1 plasmid-mediated AmpC in a salmonella enterica subsp. enterica isolate. Antimicrobial Agents and Chemotherapy, 63(10):e00992-19.

Abstract

A pan-susceptible <jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content> serovar Worthington isolate was detected in the stool of a man returning from Sri Lanka. Under ceftriaxone treatment, a third-generation cephalosporin (3GC)-resistant <jats:italic>Salmonella</jats:italic> Worthington was isolated after 8 days. Molecular analyses indicated that the two isolates were identical. However, the latter strain acquired a <jats:italic>bla</jats:italic><jats:sub>DHA-1</jats:sub>-carrying IncFII plasmid probably from a <jats:named-content content-type="genus-species">Citrobacter amalonaticus</jats:named-content> isolate colonizing the gut. This is the first report of <jats:italic>in vivo</jats:italic> acquisition of plasmid-mediated resistance to 3GCs in <jats:named-content content-type="genus-species">S. enterica</jats:named-content>.

Abstract

A pan-susceptible <jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content> serovar Worthington isolate was detected in the stool of a man returning from Sri Lanka. Under ceftriaxone treatment, a third-generation cephalosporin (3GC)-resistant <jats:italic>Salmonella</jats:italic> Worthington was isolated after 8 days. Molecular analyses indicated that the two isolates were identical. However, the latter strain acquired a <jats:italic>bla</jats:italic><jats:sub>DHA-1</jats:sub>-carrying IncFII plasmid probably from a <jats:named-content content-type="genus-species">Citrobacter amalonaticus</jats:named-content> isolate colonizing the gut. This is the first report of <jats:italic>in vivo</jats:italic> acquisition of plasmid-mediated resistance to 3GCs in <jats:named-content content-type="genus-species">S. enterica</jats:named-content>.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Food Safety and Hygiene
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Pharmacology
Health Sciences > Pharmacology (medical)
Health Sciences > Infectious Diseases
Uncontrolled Keywords:Pharmacology (medical), Pharmacology, Infectious Diseases, AmpC; DHA; Worthington; gut; plasmid-mediated resistance; treatment
Language:English
Date:29 July 2019
Deposited On:14 Feb 2020 15:37
Last Modified:29 Jul 2020 14:29
Publisher:American Society for Microbiology
ISSN:0066-4804
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/aac.00992-19
PubMed ID:31358582
Project Information:
  • : FunderSNSF
  • : Grant ID407240_177378
  • : Project TitleWhole Genome and Plasmid Sequencing for MDR Enterobacteriaceae Simultaneously Isolated from Multiple Human and Non-Human Settings: Deciphering Impact, Risks, and Dynamics for Resistance Transmission and Spread

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