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Metabolismus und Funktion der Lipoproteine hoher Dichte (HDL)


Jomard, Anne; Osto, Elena (2019). Metabolismus und Funktion der Lipoproteine hoher Dichte (HDL). Praxis, 108(7):477-486.

Abstract

Metabolism and Function of High-Density Lipoproteins (HDL) Abstract. HDL has long been considered as 'good cholesterol', beneficial to the whole body and in particular to cardio-vascular health. However, HDL is a complex particle that undergoes dynamic remodeling through interactions with various enzymes and tissue types throughout its life cycle. In this review, we explore the novel understanding of HDL as a multifaceted class of lipoprotein, with multiple subclasses of different size, molecular composition, receptor interactions, and functionality, in health and disease. Further, we report on emergent HDL based therapeutics tested in small and larger scale clinical trials and their mixed successes.

Abstract

Metabolism and Function of High-Density Lipoproteins (HDL) Abstract. HDL has long been considered as 'good cholesterol', beneficial to the whole body and in particular to cardio-vascular health. However, HDL is a complex particle that undergoes dynamic remodeling through interactions with various enzymes and tissue types throughout its life cycle. In this review, we explore the novel understanding of HDL as a multifaceted class of lipoprotein, with multiple subclasses of different size, molecular composition, receptor interactions, and functionality, in health and disease. Further, we report on emergent HDL based therapeutics tested in small and larger scale clinical trials and their mixed successes.

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Other titles:Metabolism and Function of High-Density Lipoproteins (HDL)
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
Dewey Decimal Classification:610 Medicine & health
540 Chemistry
Language:English
Date:2019
Deposited On:17 Feb 2020 16:34
Last Modified:17 Feb 2020 16:37
Publisher:Hogrefe Verlag
ISSN:1661-8157
OA Status:Closed
Publisher DOI:https://doi.org/10.1024/1661-8157/a003241
PubMed ID:31136279

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