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Homeostatic plasticity—a presynaptic perspective


Delvendahl, Igor; Müller, Martin (2019). Homeostatic plasticity—a presynaptic perspective. Current Opinion in Neurobiology, 54:155-162.

Abstract

Plastic changes in synaptic transmission are thought to underlie learning and memory formation. However, changes in synaptic function are only meaningful in the context of stable baseline function. Accumulating evidence suggests that homeostatic signaling systems actively stabilize synaptic transmission in response to neural activity perturbation. Homeostatic mechanisms control both presynaptic and postsynaptic function. Here, we review recent advances in the field of presynaptic homeostatic plasticity (PHP). We discuss PHP in the context of basic mechanisms controlling neurotransmitter release, highlight emerging similarities between different synapses in different species, and summarize new insights into the molecular mechanisms underlying this evolutionary conserved form of synaptic plasticity.

Abstract

Plastic changes in synaptic transmission are thought to underlie learning and memory formation. However, changes in synaptic function are only meaningful in the context of stable baseline function. Accumulating evidence suggests that homeostatic signaling systems actively stabilize synaptic transmission in response to neural activity perturbation. Homeostatic mechanisms control both presynaptic and postsynaptic function. Here, we review recent advances in the field of presynaptic homeostatic plasticity (PHP). We discuss PHP in the context of basic mechanisms controlling neurotransmitter release, highlight emerging similarities between different synapses in different species, and summarize new insights into the molecular mechanisms underlying this evolutionary conserved form of synaptic plasticity.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > General Neuroscience
Language:English
Date:1 February 2019
Deposited On:14 Feb 2020 14:56
Last Modified:29 Jul 2020 14:31
Publisher:Elsevier
ISSN:0959-4388
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.conb.2018.10.003
PubMed ID:30384022
Project Information:
  • : FunderSNSF
  • : Grant IDPP00P3_144816
  • : Project TitleHomeostatic Regulation of Neurotransmitter Release

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