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Regulation of Glucose Metabolism by NAD$^{+}$ and ADP-Ribosylation


Hopp, Ann-Katrin; Grüter, Patrick; Hottiger, Michael O (2019). Regulation of Glucose Metabolism by NAD$^{+}$ and ADP-Ribosylation. Cells, 8(8):pii: E890.

Abstract

Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD$^{+}$, a coenzyme in redox reactions, also mediates several ubiquitous cell signaling processes. Protein ADP-ribosylation is a post-translational modification that uses NAD$^{+}$ as a substrate and is best known as part of the genotoxic stress response. However, there is increasing evidence that NAD$^{+}$-dependent ADP-ribosylation regulates other cellular processes, including metabolic pathways. In this review, we will describe the compartmentalized regulation of NAD$^{+}$ biosynthesis, consumption, and regeneration with a particular focus on the role of ADP-ribosylation in the regulation of glucose metabolism in different cellular compartments.

Abstract

Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD$^{+}$, a coenzyme in redox reactions, also mediates several ubiquitous cell signaling processes. Protein ADP-ribosylation is a post-translational modification that uses NAD$^{+}$ as a substrate and is best known as part of the genotoxic stress response. However, there is increasing evidence that NAD$^{+}$-dependent ADP-ribosylation regulates other cellular processes, including metabolic pathways. In this review, we will describe the compartmentalized regulation of NAD$^{+}$ biosynthesis, consumption, and regeneration with a particular focus on the role of ADP-ribosylation in the regulation of glucose metabolism in different cellular compartments.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Department of Molecular Mechanisms of Disease
07 Faculty of Science > Department of Molecular Mechanisms of Disease
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:ADP-ribosylation; ARTD; Carbohydrate metabolism; NAD+; NAM; NMN; NR; PARP
Language:English
Date:13 August 2019
Deposited On:11 Mar 2020 15:06
Last Modified:11 May 2020 19:47
Publisher:MDPI Publishing
ISSN:2073-4409
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3390/cells8080890
PubMed ID:31412683

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