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Marching to another clock


Brown, Steven A; Sato, Miho (2020). Marching to another clock. Science, 367(6479):740-741.

Abstract

For several decades, researchers have studied the molecular mechanisms underlying circadian rhythms, the daily oscillations ubiquitous in biology. This basic clockwork is well understood in animal cells: Conserved clock proteins form a transcription-translation feedback loop that drives circadian oscillations of gene expression and downstream processes. These cellular clocks in peripheral tissues are hierarchically synchronized by a “master clock” in the brain [the suprachiasmatic nucleus (SCN) in mammals] responding to daylight, and also by other physiological signals such as feeding. On page 800 of this issue, Ray et al. (1) demonstrate that many circadian oscillations—in transcription, translation, and protein phosphorylation—can continue in mouse cells in the absence of an essential circadian clock gene, Bmal1 (brain and muscle ARNT-like 1). Thus, there might be other unknown clocks that also control circadian gene expression.

Abstract

For several decades, researchers have studied the molecular mechanisms underlying circadian rhythms, the daily oscillations ubiquitous in biology. This basic clockwork is well understood in animal cells: Conserved clock proteins form a transcription-translation feedback loop that drives circadian oscillations of gene expression and downstream processes. These cellular clocks in peripheral tissues are hierarchically synchronized by a “master clock” in the brain [the suprachiasmatic nucleus (SCN) in mammals] responding to daylight, and also by other physiological signals such as feeding. On page 800 of this issue, Ray et al. (1) demonstrate that many circadian oscillations—in transcription, translation, and protein phosphorylation—can continue in mouse cells in the absence of an essential circadian clock gene, Bmal1 (brain and muscle ARNT-like 1). Thus, there might be other unknown clocks that also control circadian gene expression.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Multidisciplinary
Uncontrolled Keywords:Multidisciplinary
Language:English
Date:14 February 2020
Deposited On:07 Apr 2020 07:10
Last Modified:23 Jun 2024 01:38
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1126/science.aba5336