Header

UZH-Logo

Maintenance Infos

Higher incidence of retinopathy of prematurity in extremely preterm infants associated with improved survival rates


Taner, Aylin; Tekle, Senait; Hothorn, Torsten; Adams, Mark; Bassler, Dirk; Gerth-Kahlert, Christina (2020). Higher incidence of retinopathy of prematurity in extremely preterm infants associated with improved survival rates. Acta Paediatrica:Epub ahead of print.

Abstract

AIM

This study assessed possible reasons for the increasing incidence of retinopathy of prematurity (ROP) since mid-2015 at our institution.

METHODS

Retrospective analysis of all preterm infants born July 2013 to June 2017 with a gestational age (GA) <29 completed weeks admitted to the neonatal intensive care unit at the University Hospital Zurich during the first 28 days of life. The primary outcome measures were severest ROP stage. Statistical analysis was performed using generalised additive models in R.

RESULTS

During the study period, survival increased in extremely preterm infants. Significant predictors for severest ROP stage were GA, days of mechanical ventilation and multiple gestation (P = .0322). A composite of severe comorbidities had no significant effect on severest ROP stage. GA was identified as the only significant risk factor the for severest ROP stage (P = .0045).

CONCLUSION

Increased survival rate of extremely preterm infants was associated with an increased incidence of ROP at our institution. Despite the increase, the incidence is still very low compared with other countries. No other additive factors were identified.

Abstract

AIM

This study assessed possible reasons for the increasing incidence of retinopathy of prematurity (ROP) since mid-2015 at our institution.

METHODS

Retrospective analysis of all preterm infants born July 2013 to June 2017 with a gestational age (GA) <29 completed weeks admitted to the neonatal intensive care unit at the University Hospital Zurich during the first 28 days of life. The primary outcome measures were severest ROP stage. Statistical analysis was performed using generalised additive models in R.

RESULTS

During the study period, survival increased in extremely preterm infants. Significant predictors for severest ROP stage were GA, days of mechanical ventilation and multiple gestation (P = .0322). A composite of severe comorbidities had no significant effect on severest ROP stage. GA was identified as the only significant risk factor the for severest ROP stage (P = .0045).

CONCLUSION

Increased survival rate of extremely preterm infants was associated with an increased incidence of ROP at our institution. Despite the increase, the incidence is still very low compared with other countries. No other additive factors were identified.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

1 download since deposited on 07 Apr 2020
1 download since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:28 January 2020
Deposited On:07 Apr 2020 13:56
Last Modified:29 Jul 2020 14:59
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0803-5253
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/apa.15197
PubMed ID:31991001

Download

Closed Access: Download allowed only for UZH members