Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Migration von ZORA auf die Software DSpace

ZORA will change to a new software on 8th September 2025. Please note: deadline for new submissions is 21th July 2025!

Information & dates for training courses can be found here: Information on Software Migration.

“Immune” Thrombocytopenia as Key Feature of a Novel ADA2 Deficiency Variant : Implication on Differential Diagnostics of ITP in Children

Sundin, Mikael; Marits, Per; Nierkens, Stefan; Kolios, Antonios G A; Nilsson, Jakob (2019). “Immune” Thrombocytopenia as Key Feature of a Novel ADA2 Deficiency Variant : Implication on Differential Diagnostics of ITP in Children. Journal of Pediatric Hematology/Oncology, 41(2):155-157.

Abstract

Thrombocytopenia presenting during early childhood is most commonly diagnosed as immune/idiopathic thrombocytopenic purpura (ITP), where the antibody-mediated destruction of thrombocytes is often transient. If treatment is indicated, the majority of patients respond to immune-modulation by intravenous immunoglobulin G infusion or systemic corticosteroids. Differential diagnoses to childhood ITP includes thrombocytopenia due to infections, drugs, rheumatologic conditions, immune dysregulation, and inherited bone marrow failures, for example, congenital amegakaryocytic thrombocytopenia. Isolated thrombocytopenia in an otherwise healthy appearing child that recurs after therapy and/or persists suggest a differential diagnosis rather than ITP. We present a case of symptomatic thrombocytopenia in a 2-year-old girl associated with adenosine deaminase deficiency.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Immunology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pediatrics, Perinatology and Child Health
Health Sciences > Hematology
Health Sciences > Oncology
Uncontrolled Keywords:Pediatrics, Perinatology, and Child Health, Oncology, Hematology
Language:English
Date:1 March 2019
Deposited On:14 Apr 2020 14:21
Last Modified:21 Jun 2025 02:14
Publisher:Lippincott Williams & Wilkins
ISSN:1077-4114
OA Status:Green
Publisher DOI:https://doi.org/10.1097/mph.0000000000001132
PubMed ID:29620681
Download PDF  '“Immune” Thrombocytopenia as Key Feature of a Novel ADA2 Deficiency Variant : Implication on Differential Diagnostics of ITP in Children'.
Preview
  • Content: Published Version

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
16 citations in Web of Science®
16 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

152 downloads since deposited on 14 Apr 2020
30 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications