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FeIII–salen based Probes for the Selective and Sensitive Detection of E450 in Foodstuff


Yadav, Prerna; Jakubaszek, Marta; Spingler, Bernhard; Goud, Bruno; Gasser, Gilles; Zelder, Felix (2020). FeIII–salen based Probes for the Selective and Sensitive Detection of E450 in Foodstuff. Chemistry - A European Journal, 26(25):5717-5723.

Abstract

Inorganic pyrophosphate (PPi) is considered as a diagnostic marker for various diseases such as cancer and vascular calcification. PPi also plays an important preservative role as an additive E450 in foodstuff. In this work, a selective FeIII–salen‐based probe for PPi is described; this probe disassembles in the presence of the target analyte into its molecular blocks, 1,2‐propanediamine and 3‐chloro‐5‐formyl‐4‐hydroxybenzenesulfonic acid. The latter signaling unit leads to a fluorometric response. Compared with a related prototype, the new complex shows a 2.3‐times stronger emission at 500 nm and a 155‐times better selectivity of PPi over adenosine triphosphate (ATP). Importantly, the new probe was successfully applied for detecting E450 in foodstuff.

Abstract

Inorganic pyrophosphate (PPi) is considered as a diagnostic marker for various diseases such as cancer and vascular calcification. PPi also plays an important preservative role as an additive E450 in foodstuff. In this work, a selective FeIII–salen‐based probe for PPi is described; this probe disassembles in the presence of the target analyte into its molecular blocks, 1,2‐propanediamine and 3‐chloro‐5‐formyl‐4‐hydroxybenzenesulfonic acid. The latter signaling unit leads to a fluorometric response. Compared with a related prototype, the new complex shows a 2.3‐times stronger emission at 500 nm and a 155‐times better selectivity of PPi over adenosine triphosphate (ATP). Importantly, the new probe was successfully applied for detecting E450 in foodstuff.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Catalysis
Physical Sciences > Organic Chemistry
Uncontrolled Keywords:General Chemistry
Language:English
Date:16 April 2020
Deposited On:16 Apr 2020 15:08
Last Modified:28 Jan 2021 01:00
Publisher:Wiley-VCH Verlag
ISSN:0947-6539
OA Status:Green
Publisher DOI:https://doi.org/10.1002/chem.201905686
Project Information:
  • : FunderSNSF
  • : Grant ID200021_169216
  • : Project TitleA stimuli responsive disassembly strategy as versatile tool for analytical applications
  • : FunderERC
  • : Grant IDGA 681679
  • : Project TitleERC Consolidator Grant PhotoMedMet

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