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A case series highlighting the role of different gamma-herpesviruses in Equine Multinodular Pulmonary Fibrosis


Scheurer, L; Bachofen, Claudia; Herteman, N; Hilbe, Monika; Wolfer, N; Schoster, Angelika (2020). A case series highlighting the role of different gamma-herpesviruses in Equine Multinodular Pulmonary Fibrosis. Schweizer Archiv für Tierheilkunde, 162(4):245-256.

Abstract

This case series describes three cases of equine multinodular pulmonary fibrosis (EMPF) diagnosed at the Clinic for Equine Internal Medicine at the University of Zurich between 2012 and 2017. Current information on etiology and treatment options are presented. Two horses showed mild signs of chronic lower respiratory tract disease and one horse was presented with acute signs of disease including recurrent fever spikes and tachypnea. Diagnosis was achieved by physical examination, radiographic findings, and PCR testing for equine herpesviruses (EHV) of bronchoalveolar lavage (BAL) fluid or lung tissue obtained by biopsy. All horses were euthanized due to continuing deterioration after attempted treatment. Post mortem histological examination of lung tissue showed severe multifocal diffuse to confluent fibrosis in two cases and in another horse a discrete nodular fibrosis pattern. Panherpes nested PCR revealed the presence of equine herpesvirus 5 (EHV-5) DNA in lung tissue of one horse whereas in two other horses, asinine herpes virus 5 (AHV-5) was detected. EMPF should be considered as a differential diagnosis in horses with acute and chronic respiratory disease, including horses non-responsive to treatment for equine asthma.

Abstract

This case series describes three cases of equine multinodular pulmonary fibrosis (EMPF) diagnosed at the Clinic for Equine Internal Medicine at the University of Zurich between 2012 and 2017. Current information on etiology and treatment options are presented. Two horses showed mild signs of chronic lower respiratory tract disease and one horse was presented with acute signs of disease including recurrent fever spikes and tachypnea. Diagnosis was achieved by physical examination, radiographic findings, and PCR testing for equine herpesviruses (EHV) of bronchoalveolar lavage (BAL) fluid or lung tissue obtained by biopsy. All horses were euthanized due to continuing deterioration after attempted treatment. Post mortem histological examination of lung tissue showed severe multifocal diffuse to confluent fibrosis in two cases and in another horse a discrete nodular fibrosis pattern. Panherpes nested PCR revealed the presence of equine herpesvirus 5 (EHV-5) DNA in lung tissue of one horse whereas in two other horses, asinine herpes virus 5 (AHV-5) was detected. EMPF should be considered as a differential diagnosis in horses with acute and chronic respiratory disease, including horses non-responsive to treatment for equine asthma.

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Other titles:Die Rolle von verschiedenen Gamma-herpesviren in einer Fallserie von Equiner multinodulärer pulmonalen Fibrose
Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
05 Vetsuisse Faculty > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Institute of Virology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Clinical Diagnostics and Services
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Health Sciences > General Veterinary
Uncontrolled Keywords:Asinin-Herpesvirus 5; Equines Herpes­virus 5; Pferd; interstitielle Pneumonie; Lungenfibrose; asinine herpes virus 5; equine herpesvirus 5; horse; interstitial pneumonia; pulmonary fibrosis; virus dell’herpes asinino 5; herpesvirus equino 5; cavalli; polmonite interstiziale; fibrosi polmonare; virus herpès asinien 5; l’virus herpès équin 5; cheval; pneumonie interstitielle; fibrose pulmonaire
Language:English
Date:April 2020
Deposited On:21 Apr 2020 15:38
Last Modified:06 May 2020 20:14
Publisher:Gesellschaft Schweizer Tierärztinnen und Tierärzte
ISSN:0036-7281
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.17236/sat00255
PubMed ID:32234694

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