Food is an organic need and essential to our survival, whereas nutraceuticals and pharmaceuticals play an important role in disease prevention and cure. The food processing and healthcare industries are often linked together for economic growth and health promotion. However, the complexity of the ingredients and processes led communities to question their motivation, accuracy, and imposed standards. Different standards are often applied to ensure high quality, reproducibility, and traceability. Many processed products contain ingredients derived from animals, where the consumption of such products is prohibited by several religions and lifestyles. Patients who want to avoid certain medications derived from animal need to know the source of origin and detailed ingredients contained in their medicines. Recently many Muslim and non-Muslim countries have realized the value of Halal products and led to an increase in Halal awareness. This chapter aims to provide more insight into the issue of Halal status of food and medications in the context of healthcare and describe the process of certification and the list of ingredients and drugs with potential non-Halal sources. Traceability procedure and identification of a long list of ingredients is a challenge but also key for verifying the Halal status of the end product. Implementation of Halal-Tayyib concept is essential to determine the Halalness of food and pharmaceuticals. To increase confidence, eliminate suspicion, and improve trust with producers, Halal certification is required. However, exerting 100% effort is possible, whereas achieving products that are 100% clean and pure and comply with Shari’ah is debatable.