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Poirel, Laurent; Vuillemin, Xavier; Juhas, Mario; Masseron, Amandine; Bechtel-Grosch, Ursina; Tiziani, Simon; Mancini, Stefano; Nordmann, Patrice (2020). KPC-50 confers resistance to ceftazidime-avibactam associated with reduced carbapenemase activity. Antimicrobial Agents and Chemotherapy, 64(8):e00321-20.
KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate recovered in Switzerland in 2019. As compared to KPC-3, KPC-50 shows i) a three amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277 amino acid sequence, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (iv) associated to a sharp reduction of its carbapenemase activity.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Department of Trauma Surgery
04 Faculty of Medicine > University Hospital Zurich > Institute of Intensive Care Medicine 04 Faculty of Medicine > Institute of Medical Microbiology |
| Dewey Decimal Classification: | 610 Medicine & health |
| Language: | English |
| Date: | 26 May 2020 |
| Deposited On: | 03 Jun 2020 10:46 |
| Last Modified: | 23 Dec 2024 02:38 |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| OA Status: | Hybrid |
| Free access at: | PubMed ID. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1128/AAC.00321-20 |
| PubMed ID: | 32457107 |
Poirel, Laurent